AGRYLIN (Anagrelide)
AGRYLIN (Anagrelide)
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AGRYLIN (Anagrelide)

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What is this medication? 

AGRYLIN (Anagrelide)
Antiplatelet Agent; Phosphodiesterase-3 Enzyme Inhibitor

AGRYLIN (Anagrelide) is indicated for treatment of essential thrombocythemia.

How does this medication work? 

AGRYLIN (Anagrelide) causes a dosage-dependant reduction in platelets from decreasing megakaryocyte hypermaturation.  It also inhibits cyclic nucleotide phosphodiesterase and the release of arachidonic acid from phospholipase, possibly by inhibiting phospholipase A2.

How should I take this medication?

Oral: Take 0.5mg 4 times daily or 1mg 2 times daily for at least 1 week. Then take 1.5 to 3 mg daily as a maintenance dose.

Note: Maximum single dose = 2.5 mg; maximum daily dose = 10 mg. Increase dosage by no more than 0.5 mg/day in any 1 week.

How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same times each day unless otherwise directed. May be administered without regard to food.

What should I watch for while using this medication? 

Before starting AGRYLIN (Anagrelide), make sure your physician is aware of any allergies or medications you currently take, if you have hepatic impairment, are pregnant, or breastfeeding. Anagrelide use has been associated with rare but serious adverse events such as increased risk of major hemorrhagic event, cardiac conductivity disturbances, pulmonary hypertension, pulmonary toxicity, and renal abnormalities.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication? 

Edema, palpitations, abdominal pain, diarrhea, nausea, dizziness, headache, pain, asthenia.

Note this is not a complete list of side effects for AGRYLIN (Anagrelide), only common ones.