AKYNZEO (Netupitant/Palonosetron)

AKYNZEO (Netupitant/Palonosetron)

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What is this medication? 

AKYNZEO (Netupitant/Palonosetron)
Antiemetic; Selective 5-HT3 Receptor Antagonist; Substance P/Neurokinin 1 Receptor Antagonist

AKYNZEO (Netupitant/Palonosetron) is indicated for treatment of chemotherapy-induced nausea and vomiting.

How does this medication work? 

Fosnetupitant is a prodrug of Netupitant, which is a selective substance P/neurokinin (NK1) receptor antagonist.  Netupitant augments the antiemetic activity of 5-HT3 receptor antagonists and corticosteroids to prevent acute and delayed chemotherapy-induced emesis. The oral form of AKYNZEO uses Netupitant, whereas the IV formulation uses the prodrug Fosnetupitant. Palonosetron is a selective 5-HT3 receptor antagonist, which blocks serotonin, both on vagal nerve terminals in the periphery and centrally in the chemoreceptor trigger zone. Palonosetron inhibits the cross-talk between the 5-HT3 and NK1 receptors. The combination of palonosetron and Netupitant works synergistically to inhibit substance P response to a greater extent than either agent alone.

How should I take this medication? 

Oral: Take one capsule (netupitant 300 mg and palonosetron hydrochloride 0.5 mg) 1 hour before chemotherapy on day 1.

What should I watch for while using this medication?

Before starting AKYNZEO (Netupitant/Palonosetron), make sure your physician is aware of any allergies or medications you currently take, if you have renal impairment, hepatic impairment, are pregnant, or breastfeeding. AKYNZEO use has been associated with rare but serious adverse events such as hypersensitivity reactions and serotonin syndrome. 

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Headache, fatigue, erythema, dyspepsia, constipation, weakness.

Note this is not a complete list of side effects for AKYNZEO (Netupitant/Palonosetron), only common ones.