ALOXI (Palonosetron)

ALOXI (Palonosetron)

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What is this medication? 

ALOXI (Palonosetron)
Antiemetic; Selective 5-HT3 Receptor Antagonist

ALOXI (Palonosetron) is indicated for the treatment of chemotherapy-induced nausea and vomiting; postoperative nausea and vomiting.

How does this medication work? 

ALOXI (Palonosetron) is a selective 5-HT3 receptor antagonist, which blocks serotonin, both on vagal nerve terminals in the periphery and centrally in the chemoreceptor trigger zone. Palonosetron inhibits the crosstalk between the 5-HT3 and NK1 receptors.

How should I take this medication? 

Oral: Take 0.5 mg ~1 hour prior to the start of chemotherapy.

How to Take: Take capsule with or without food. 

What should I watch for while using this medication? 

Before starting ALOXI (Palonosetron), make sure your physician is aware of any allergies or medications you currently take, if you are pregnant, or breastfeeding. Palonosetron use has been associated with rare but serious adverse events such as hypersensitivity reactions, serotonin syndrome, and ECG changes.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication? 

Pruritis, hyperkalemia, constipation, diarrhea, flatulence, urinary retention, headache, bradycardia, hypotension.

Note this is not a complete list of side effect for ALOXI (Palonosetron), only common ones.