AMILZIDE (Amiloride/ Hydrochlorothiazide)

AMILZIDE (Amiloride/ Hydrochlorothiazide)

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What is this medication? 

AMILZIDE (Amiloride/Hydrochlorothiazide)
Antihypertensive, Diuretic, Combination

AMILZIDE (Amiloride/Hydrochlorothiazide) is indicated for prevention/management of heart failure, and hypertension.

May cause hyperkalemia (serum potassium levels greater than 5.5 mEq per liter) which, if uncorrected, is potentially fatal.

How does this medication work? 

Amiloride blocks sodium channels in the distal convoluted tubule (DCT) of the nephron which inhibits sodium reabsorption. This leads to potassium retention, decrease in calcium, magnesium and hydrogen excretion. The natriuretic, diuretic and antihypertensive effects of Amiloride are independent of aldosterone.

Hydrochlorothiazide lowers blood pressure by inhibiting sodium reabsorption in the distal tubules which causes increased loss of sodium, water, potassium, and hydrogen ions (lower blood volume results in decreased pressure). It is also believed to lower peripheral vascular resistance (by relaxing blood vessels).

How should I take this medication? 

Oral: Take 1 tablet daily. Once initial diuresis has been achieved, dosage adjustment may be increased to 2 tablets daily.

How to Take: Take with food.

What should I watch for while using this medication? 

Before starting AMILZIDE (Amiloride/Hydrochlorothiazide), make sure your physician is aware of any allergies or medications you currently take. The usage of AMILZIDE can cause electrolyte disturbances (i.e. decrease in sodium and chloride, increase in BUN) and significant hyperkalemia. It is very important that your doctor monitor electrolytes routinely when on AMILZIDE. Discontinue if hyperkalemia develops.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light.  Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication? 

Cardiac arrhythmia, dizziness, headache, fatigue, skin rash, pruritus, hyperkalemia, increased serum potassium, nausea, abdominal pain, diarrhea , gastrointestinal pain, leg pain, weakness, dyspnea.

Note this is not a complete list of side effects for AMILZIDE (Amiloride/Hydrochlorothiazide), only common ones.