BARACLUDE (Entecavir)
BARACLUDE (Entecavir)
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BARACLUDE (Entecavir)

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What is this medication? 

BARACLUDE (Entecavir)
Antihepadnaviral, R
everse Transcriptase Inhibitor, Nucleoside (Anti-HBV)

BARACLUDE (Entecavir) is indicated for treatment of chronic hepatitis B.

Severe Acute Exacerbations of Hepatitis B:
Severe acute exacerbations of hepatitis B have been reported in patients who have discontinued antihepatitis B therapy, including Entecavir. Closely monitor hepatic function with clinical and laboratory follow-up for at least several months in patients who discontinue antihepatitis B therapy. 

HIV and Chronic Hepatitis B Virus Coinfection:
Limited clinical experience suggests there is a potential for the development of resistance to HIV nucleoside reverse transcriptase inhibitors if Entecavir is used to treat chronic hepatitis B virus (HBV) infection in patients with HIV infection not being treated. Therapy with Entecavir is not recommended for HIV/HBV coinfected patients who are not also receiving antiretroviral therapy.

Lactic Acidosis and Hepatomegaly:
Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogue inhibitors alone or in combination with antiretrovirals.

How does this medication work? 

BARACLUDE (Entecavir) is phosphorylated to guanosine triphosphate which competes with natural substrates to effectively inhibit hepatitis B viral polymerase; enzyme inhibition blocks reverse transcriptase activity thereby reducing viral DNA synthesis.

How should I take this medication? 

Oral: Take 0.5mg to 1mg once daily.

How to Take: Take on an empty stomach, 2 hours before or after a meal. Do not dilute or mix oral solution with water or other beverages; use calibrated oral dosing syringe. Oral solution and tablet are bioequivalent on a mg-to-mg basis.

What should I watch for while using this medication? 

Before starting BARACLUDE (Entecavir), make sure your physician is aware of any allergies or medications you currently take.  Lactic acidosis and severe hepatomegaly with steatosis have been reported when using nucleoside analogue inhibitors such as Entecavir. Use Entecavir with caution in patients with renal and/or hepatic impairment.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication? 

Elevated liver enzymes, headache, fatigue, skin rash, glycosuria, hyperglycemia, abdominal pain, diarrhea, unpleasant taste, dyspepsia, hematuria.

Note this is not a complete list of side effects for BARACLUDE (Entecavir), only common ones.