PARLODEL (Bromocriptine)
PARLODEL (Bromocriptine)
PARLODEL (Bromocriptine)
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PARLODEL (Bromocriptine)

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What is this medication?

PARLODEL (Bromocriptine)
Anti-Parkinson Agent, Dopamine Agonist, Antidiabetic Agent, Ergot Derivative

PARLODEL (Bromocriptine) is an ergoline derivative and dopamine agonist that is indicated for the treatment of pituitary tumors, Parkinson's disease, hyperprolactinaemia, neuroleptic malignant syndrome, and, as an adjunct, type 2 diabetes.

How does this medication work? 

PARLODEL (Bromocriptine) is an ergot alkaloid derivative and a dopamine agonist which binds to post-synaptic receptors to inhibit pituitary prolactin secretion and enhance coordinated motor control.  Prolactin is best known for stimulating lactorrhea but also have been found to be linked to sexual libido and penile erection.  Studies have shown that the neuroendocrine response to sexual activity is characterized by a pronounced orgasm-dependent increase in prolactin levels.  Men who have higher prolactin levels are likely to experience lower sexual drive and erectile dysfunction Bromocriptine has been shown to have a positive impact in the treatment of sexual disorders as well as help improve overall sexual performance by reducing the duration of refractory period, improve sexual libido and arousal and improving overall penile erectile function.  In addition, Bromocriptine is believed to reset the hypothalamic circadian rhythm which can reverse insulin resistance and decrease glucose production in obese patients along with maintaining normal leptin stimulation during caloric restriction which will normalize the metabolic rate.

How should I take this medication? 

Oral: Take 1.25mg to 2.5mg daily; dose may be increased by 2.5mg daily as tolerated every 2 to 7 days until optimal response is reached (therapeutic range: 2.5mg to 15mg daily).

Parkinson disease
Oral: Take 0.8mg once daily in the morning; dose can be increased by 0.8mg weekly as tolerated (therapeutic range: 1.6mg to 4.8mg daily).

How to Take: Take with food to decrease any GI upset.  Take the medication exactly as prescribed by your doctor at the same time each day.

What should I watch for while using this medication? 

Before starting PARLODEL (Bromocriptine), make sure your physician is aware of any allergies, medications you take, current medical conditions, and if you have a known hypersensitivity to Bromocriptine.  Bromocriptine can cause cardiac valvular fibrosis, CNS depression, and pleural/retroperitoneal fibrosis. Bromocriptine can reduce impulse control and has been associated with compulsive behaviors.  Do not use if you have uncontrolled hypertension and/or pregnant.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Constipation, nausea, dizziness, headache, asthenia, rhinitis.

Note this is not a complete list of side effects for PARLODEL (Bromocriptine), only common ones.