BYDUREON (Exenatide)

BYDUREON (Exenatide)

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prescription refrigerated

What is this medication?

BYDUREON (Exenatide)
Antidiabetic Agent, Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist

BYDUREON (Exenatide) is officially indicated for the treatment of Diabetes mellitus type 2.

How does this medication work? 

BYDUREON (Exenatide) is an analog of human glucagon-like peptide-1 (GLP-1) (an incretin hormone).  Exenatide works in multiple of ways to lower blood glucose and hemoglobin A1C.  Exenatide stimulates the beta cells of the pancreas to release insulin when blood glucose levels are high.  Exenatide slow down gastric emptying and the rate at which glucose enters the blood after meals.  Exenatide also helps lower hepatic glucose output by suppressing pancreatic glucagon secretion.

How should I take this medication? 

SQ: Inject 2 mg subcutaneously once weekly without regard to meals. If changing the day of administration is necessary, allow at least 3 days between 2 doses. 

How to Take: Administer via subcutaneous injection in the upper arm, thigh, or abdomen; rotate injection sites. If using concomitantly with insulin, administer as separate injections (do not mix); may inject in the same body region as insulin, but not adjacent to one another. Do not inject IV or IM.

What should I watch for while using this medication? 

Before starting BYDUREON (Exenatide), make sure your physician is aware of any allergies, and medications you currently take. Exenatide has been reported to cause hemorrhagic and necrotizing pancreatitis. The risk of hypoglycemia is higher when Exenatide is combined with sulfonylurea. Exenatide should not be used in patients with severe renal impairment or end-stage renal disease and/or severe gastrointestinal disease.

What if I miss a dose?

Missed doses BYDUREON should be administered as soon as possible if the next scheduled dose is due in ≥3 days, then resume usual schedule thereafter. If there are <3 days until next scheduled dose, omit the missed dose and resume administration at the next scheduled weekly dose.

How should I store this medication?

Prior to first use, BYDUREON (Exenatide) must be stored refrigerated at 2°C to 8°C. Do not freeze, and do not use if it has been frozen. After first use of the pen, store at 2°C to 25°C. The pen should be discarded 30 days after first use, even if some drug remains in the pen. Do not store pen with the needle attached. Keep out of reach of children and pets.

What are the possible side effects of using this medication?

Nausea, hypoglycemia, vomiting, diarrhea, feeling jittery, dizziness, headache, dyspepsia.

Note this is not a complete list of side effects for BYDUREON (Exenatide), only common ones.