CIPRODEX (Ciprofloxacin/ Dexamethasone)

CIPRODEX (Ciprofloxacin/ Dexamethasone)

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What is this medication?

CIPRODEX (Ciprofloxacin/Dexamethasone)
Otic Antibiotic (Fluoroquinolone); Otic Corticosteroid

CIPRODEX (Otic), a combination of of Ciprofloxacin and Dexamethasone is indicated for the treatment of acute otitis externa.

How does this medication work?

Ciprofloxacin inhibits DNA gyrase in bacteria which is important in protein synthesis.  Blocking DNA gyrase results inhibits relaxation of supercoiled DNA so it cannot be used for protein synthesis and promotes the breakage of double stranded DNA eventually causing cell death.  Humans do not have DNA gyrase which makes it an ideal target for antibiotics.

Dexamethasone reduces neutrophil migration to the affected area and reverses the dilation and blood vessel permeability from the inflammatory response resulting in decreased access of cells to the site.  It also reduces lymphatic flow to the area which reduces immune activity.

What should I watch for while using this medication?

Before starting CIPRODEX (Ciprofloxacin/Dexamethasone), make sure your physician is aware of any allergies or medications you currently take, if you are pregnant, or breastfeeding.

How should I take this medication?

Otic: Instill 4 drops into the affected ear(s) twice a day.

Note: Do not instill into ear if cold, warm medication to room temperature before administration to avoid dizziness.

How to Take: Follow instructions provided by physician/pharmacy label, use consistently at same times each day unless otherwise directed. Shake well before use, keep head tilted for 60 seconds after application. Not for ophthalmic use.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose.  Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times.  Store at room temperature, 20 to 25° C (68 to 77° F).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Local Pruritis (itch), and otalgia (ear pain).

Note this is not a complete list of side effects for CIPRODEX (Ciprofloxacin/Dexamethasone), only common ones.