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What is this medication? 


Cloxacillin is indicated for treatment of bacterial infections.

How does this medication work? 

Cloxacillin exhibits bactericidal activity via inhibition of bacterial cell wall synthesis by binding to penicillin binding proteins (PBPs) which activates bacterial autolysis.

How should I take this medication? 

Oral: Take 250 to 500 mg every 6 hours (maximum adult dose: 6 g/day).

Note: Dose and duration of therapy can vary depending on infecting organism, severity of infection, and clinical response of patient. Treat severe staphylococcal infections for at least 14 days; endocarditis and osteomyelitis require an extended duration of therapy for 4 to 6 weeks. The intravenous route should be used for severe infections.

How to Take: For capsules, take with water 1 hour before or 2 hours after meals. For oral solution, shake well before taking. Administer liquid with an accurate measuring device; do not use a household teaspoon (under- or over dosage may occur).

What should I watch for while using this medication? 

Before using Cloxacillin make sure your physician is aware of any allergies, medications you currently take, pre-existing medical conditions and activities you perform.  Cloxacillin has been associated with hematologic disorders such as agranulocytosis, neutropenia, and thrombocytopenia. Prolonged use of Cloxacillin can cause fungal or bacterial superinfections. Use Cloxacillin with caution in patients with renal impairment and/or history of seizure disorders.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication? 

Hypotension, thrombophlebitis, confusion, lethargy, myoclonus, seizure (high doses and/or renal failure), twitching, pruritus, skin rash, urticaria, abdominal pain, diarrhea, epigastric distress, flatulence, hairy tongue, loose stools, melanoglossia, nausea, oral candidiasis, pseudomembranous colitis, stomatitis, vomiting, hematuria, proteinuria, agranulocytosis, anemia, bone marrow depression, eosinophilia, granulocytopenia, hemolytic anemia, immune thrombocytopenia, leukopenia, neutropenia, thrombocytopenia, increased serum alkaline phosphatase, increased serum ALT, increased serum AST, hepatotoxicity, anaphylaxis, angioedema, hypersensitivity reaction (immediate and delayed), serum sickness-like reaction, laryngospasm, interstitial nephritis, renal insufficiency, renal tubular disease, bronchospasm, laryngeal edema, sneezing, wheezing, fever.

Note this is not a complete list of side effects for Cloxacillin, only common ones.