COTELLIC (Cobimetinib)

COTELLIC (Cobimetinib)

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What is this medication?

COTELLIC (Cobimetinib)
Antineoplast Agent, MEK Inhibitor

COTELLIC (Cobimetinib) is a kinase inhibitor indicated for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, in combination with vemurafenib.

How does this medication work? 

COTELLIC (Cobimetinib) is a potent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway which regulates the extracellular signal-related kinase (ERK) pathway. The ERK pathway promotes cellular proliferation.  Cobimetinib has been shown to increase apoptosis and reduce overall tumor growth.

How should I take this medication? 

Oral: Take 60mg once daily from days 1 to 21 of each 28-day treatment cycle.

How to Take: Take with or without food.  Swallow whole; do not crush, cut or chew the tablet.

What should I watch for while using this medication? 

Before starting COTELLIC (Cobimetinib), make sure your physician is aware of any allergies or medications you currently take.  Cobimetinib has been reported to cause new malignancies which require monitoring for up to 6 months following therapy.  Cobimetinib has also been associated with other serious adverse effects such as hemorrhage, cardiomyopathy, dermatologic toxicity, hepatotoxicity, hypertension, cutaneous malignancies, ophthalmic effects and rhabdomyolysis.

What if I miss a dose?

If a dose is missed or if vomiting occurs after a dose is taken, resume with the next scheduled dose (do not take an additional dose).

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Reduction in ventricular ejection fraction, hypertension, photosensitivity, acneiform eruption, elevated liver enzymes, electrolyte disturbances, diarrhea, nausea, vomiting, stomatitis, hematologic disturbances (i.e. lymphocytopenia, anemia, thrombocytopenia, hemorrhage, ecchymoses, epistaxis, gingival hemorrhage, hematemesis, visual impairment, retinal detachment, fever, chills, skin rash, keratoacanthoma, squamous cell carcinoma of the skin and gastrointestinal and genitourinary hemorrhage.

Note this is not a complete list of side effects for COTELLIC (Cobimetinib), only common ones.