CRINONE (Progesterone)

CRINONE (Progesterone)

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What is this medication?

CRINONE (Progesterone)

Progesterone (Vaginal Gel) is officially indicated for treatment of amenorrhea or abnormal uterine bleeding and as part of assisted reproductive technology (ART) for infertile women with progesterone deficiency.

How does this medication work? 

CRINONE (Progesterone) is a steroid hormone that plays a regulatory role in the female reproductive system by allowing the endometrium to transition from a proliferative to the secretory stage, facilitates blastocyst nesting and is essential to the maintenance of pregnancy.  Progesterone also plays an important role in several tissues not belonging to the reproductive system, such as the mammary gland in preparation for breastfeeding, the cardiovascular system, central nervous system, and bones.

How should I take this medication? 

Amenorrhea (Secondary)
Intravaginal Gel: Insert/Apply gel 45mg (4%) gel every other day for up to a total of 6 doses; if response if inadequate you can increase to using 90mg (8%) gel every other day for up to a total of 6 doses.

ART in women requiring progesterone supplementation
Intravaginal Gel: Insert/Apply 90mg (8%) gel once daily.  If pregnancy occur, may continue treatment for up to 10 to 12 weeks.

ART in women with partial or complete ovarian failure
Intravaginal Gel: Insert/Apply 90mg (8%) gel twice daily.  If pregnancy occurs, continue treatment for up to 10 to 12 weeks.

How to Take: Remove applicator from wrapper, holding the applicator on each side, push plunger into applicator until it snaps into place. Administer the gel directly into the vagina by pressing down on the plunger. Do not use concomitantly with other local vaginal therapy. If concomitant therapy cannot be avoided, administer other vaginal products at least 6 hours before or 6 hours after progesterone administration.

What should I watch for while using this medication?

Before starting CRINONE (Progesterone), make sure your physician is aware of any allergies or medications you currently take, if you are pregnant, or breastfeeding.  Avoid using progesterone gel if you have hypersensitivity to progesterone or any component of the formulation, including palm oil.  Avoid using progesterone gel if you have undiagnosed vaginal bleeding, hepatic impairment or disease, known or suspected malignancy of the breast or genital organs, missed abortion, active thrombophlebitis or thromboembolic disorders, or a history of hormone-associated thrombophlebitis or thromboembolic disorders.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Drowsiness, headache, nervousness, depression, constipation, nausea, muscle cramps, abdominal pain, breast hypertrophy, perineal pain, mastalgia, nocturia.

Note this is not a complete list of side effects for CRINONE (Progesterone), only common ones.