Desipramine
Desipramine
Desipramine
Desipramine
Desipramine
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Desipramine

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prescription

What is this medication?

NORPRAMIN (Desipramine)
Antidepressant, Tricyclic 

NORPRAMIN (Desipramine) is indicated for the treatment of depression.

ALERT: WARNING
Antidepressants increased the risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Closely observe and appropriately monitor patients of all ages who are started on antidepressant therapy for clinical worsening, suicidality, or unusual changes in behavior. Advise families and caregivers of the need for close observation and communication with the prescribing health care provider.

How does this medication work? 

NORPRAMIN (Desipramine) increases the synaptic concentration of norepinephrine (and to a lesser extent, serotonin) in the central nervous system by inhibition of its reuptake by the presynaptic neuronal membrane. However, additional receptor effects have been found including desensitization of adenyl cyclase, down regulation of beta-adrenergic receptors, and down regulation of serotonin receptors.

How should I take this medication? 

Oral: Take 25mg to 300mg once daily.

How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same times each day unless otherwise directed. Generally taken 1-3 hour prior to bed to minimize daytime drowsiness.

What should I watch for while using this medication? 

Before starting NORPRAMIN (Desipramine), make sure your physician is aware of any allergies or medications you currently take.  Desipramine like any other antidepressant can increase the risk of suicidal thinking and behavior in children, adolescents, and young adults (18 to 24 years of age) with major depressive disorder (MDD) and other psychiatric disorders; consider risk prior to prescribing.  Desipramine may cause anticholinergic effects (i.e. constipation, xerostomia, blurred vision, urinary retention), central nervous system depression, fragility fracture, ocular effects, orthostatic hypotension, serotonin syndrome.  Desipramine, should be used with caution in patients with pre-existing cardiovascular disease because of the risk of conduction abnormalities, diabetes, hepatic and/or renal impairment, with a history of seizures.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Dry mouth, disturbances of visual accommodation, constipation, mild urinary retention, light headedness, drowsiness, increased perspiration, mild tremors, insomnia.

Note this is not a complete list of side effects for NORPRAMIN (Desipramine), only common ones.