DIPRIVAN 1% (Propofol)
DIPRIVAN 1% (Propofol)
DIPRIVAN 1% (Propofol)
DIPRIVAN 1% (Propofol)
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DIPRIVAN 1% (Propofol)

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ASPEN PHARMACARE
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$98.99 USD
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What is this medication?

DIPRIVAN (Propofol)
General anesthesia

DIPRIVAN (Propofol) is a general anesthesia, mechanically ventilated patients in the ICU for sedation.

ALERT: WARNING
FDA has issued an emergency authorization (EUA) during the COVID-19 pandemic to permit the emergency use of the unapproved product Propofol-Lipuro 1% (propofol 10mg/ml) emulsion for infusion. The EUA allows for Propofol-Lipuro to be distributed in the United States and administered only by a licensed health care provider in an intensive care unit (ICU) setting.

How does this medication work? 

DIPRIVAN (Propofol) is an intravenous anesthetic that works by increasing GABA-mediated activity through NMDA receptors causing CNS depression.

How should I take this medication? 

IV: Induction intravenous infusion of 0.5 to 2.5mg/kg.  Maintenance intravenous infusion of 50 to 200mcg/kg/minutes; titrate to clinical response.

Note: for obese patients, use adjusted body weight for initial weight-based dosing.  Individualize dosing based on patient factors and concomitant anesthetic agents.

How to Take: Administer DIPRIVAN (Propofol) as an intermittent bolus or by continuous IV infusion.  Strict aseptic technique must be maintained in handling although a preservative has been added.  Do not use if contamination is suspected.  To reduce pain associated with injection, use larger veins of forearm or antecubital fossa; lidocaine IV (1 mL of a 1% solution) may also be used prior to administration or it may be added to Propofol immediately before administration in a quantity not to exceed 20 mg lidocaine per 200 mg Propofol. Do not use filter <5 micron for administration.

What should I watch for while using this medication? 

Before starting DIPRIVAN (Propofol), make sure your physician is aware of any allergies or medications you currently take, and any existing medical conditions.  Propofol use has been associated with prolongation of the QT interval, hypertriglyceridemia, hypotension and injection site irritation.  Propofol-related infusion syndrome (PRIS) is a serious side effect with a high mortality rate (up to 33%) characterized by dysrhythmia, heart failure, hyperkalemia, lipemia, metabolic acidosis, and/or rhabdomyolysis or myoglobinuria with subsequent renal failure.  Propofol should be used with caution in patients with severe cardiac disease (ejection fraction < 50%) or hypotension, elevated intracranial pressure, pancreatitis, respiratory disease, and seizure disorders.  Propofol should never be taken concomitantly with opioids because of increased sedative or anesthetic effects of Propofol resulting in decreases in blood pressure and cardiac output.

What if I miss a dose?

DIPRIVAN (Propofol) is used when needed and does not have a daily dosing schedule. Since Propofol is given by a healthcare professional in a medical setting, you are not likely to miss a dose.

How should I store this medication?

Store between 2° and 25°C.  Do not freeze. The emulsion should be visually inspected for particulate matter, emulsion separation and/or discolouration prior to use. Do not use if any of these things are seen. If no signs of particulate matter, emulsion separation and/or discolouration are seen, shake gently before use. Any unused portions of DIPRIVAN (Propofol) should be discarded at the end of the surgical procedure.

What are the possible side effects of using this medication?

Hypotension, involuntary body movements, burning and pain at the injection site, apnea.

Note this is not a complete list of side effects for DIPRIVAN (Propofol), only common ones.