EFUDEX/TOLAK (Fluorouracil)

EFUDEX/TOLAK (Fluorouracil)

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What is this medication?

EFUDEX/TOLAK (Fluorouracil)
Antineoplastic Agent; Antimetabolite; Pyrimidine Derivative

EFUDEX/TOLAK (Fluorouracil) is officially indicated for the treatment of actinic or solar keratosis and basal cell carcinoma.

How does this medication work? 

EFUDEX/TOLAK (Fluorouracil) is pyrimidine antimetabolite that interferes with DNA synthesis by blocking the methylation of deoxyuridylic acid to thymidylic acid; blocks DNA synthesis to prevent cell proliferation of fast-growing cells and cause cell death.

How should I take this medication? 

Actinic or Solar Keratosis
Cream (0.5%): Apply thin film to lesions once daily for up to 4 weeks, as tolerated.

Cream (1%): Apply to lesions twice daily for 2 to 6 weeks.

Cream (4%): Apply to lesions once daily for 4 weeks as tolerated.

Cream (5%) or solution (2% and 5%): Apply to lesions twice daily for 2 to 4 weeks; complete healing may not be evident for 1 to 2 months following treatment.

Superficial Basal Cell Carcinoma
Cream (5%) or solution (5%):
Apply to affected lesions twice daily for 3 to 6 weeks; treatment may be continued for up to 10 to 12 weeks.

How to Take:  Only apply after 10 minutes of washing and drying the affected areas.  Apply using a non-metal applicator or latex/non-latex glove.  Do not cover the area with an occlusive dressing.  Topical preparations are for external use only; do not apply to the eye, eyelids, mouth, and/or mucous membranes.

What should I watch for while using this medication? 

Before starting EFUDEX/TOLAK (Fluorouracil),make sure your physician is aware of any allergies or medications you currently take. Delayed hypersensitivity reactions, including allergic contact dermatitis, pruritis and/or eczema can occur at the application site or at a distant site. Local skin reactions can occur when applied to a lesion.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Application site scaling, application site dryness, stinging of the skin, skin erosion, application site erythema, application site reaction, application site burning, application site pruritus, application site edema, application site pain.

Note this is not a complete list of side effects for EFUDEX/TOLAK (Fluorouracil), only common ones.