EMGALITY (Galcanezumab)
EMGALITY (Galcanezumab)
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EMGALITY (Galcanezumab)

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prescription refrigerated

What is this medication?

EMGALITY (Galcanezumab)
Antimigraine Agent; Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist; Monoclonal Antibody

EMGALITY (Galcanezumab) is indicated for the treatment of cluster headaches, migraine prophylaxis.

How does this medication work?

EMGALITY (Galcanezumab) is a humanized monoclonal antibody that binds to the vasodilator calcitonin gene-related peptide (CGRP) ligand and blocks its binding to the receptor and blocks the transmission of pain in the brain.

How should I take this medication?

Cluster headache
 Inject 300mg subcutaneously at the onset of the cluster period and then once monthly until the end of the cluster period.

Migraine prophylaxis
SQ: Initial 240mg subcutaneously as a single loading dose, followed by 120mg subcutaneously once monthly.

How to Take: For subcutaneous use only; intended for self-administration. Prior to administration, allow it to come to room temperature for 30 minutes. Do not warm using a heat source.  Do not shake. Administer in abdomen (avoiding 2 inches around the navel), thigh, upper arm, or buttocks avoiding areas of skin that are tender, bruised, red or hard.  Deliver entire contents of single-use prefilled pen or syringe. Administer the 240 mg loading dose as 2 injections of 120 mg, one after another, and the 300 mg dose as 3 injections of 100 mg, one after another.

What should I watch for while using this medication?

Before using EMGALITY (Galcanezumab), make sure your physician is aware of any allergies or medications you currently take, pre-existing medical conditions and activities you perform. Galcanezumab should be used with caution in patients with who have a recent history (within 6 months) of stroke, myocardial infarction, unstable angina, percutaneous coronary intervention, coronary artery bypass grafting, deep vein thrombosis, or pulmonary embolism. Use Galcanezumab with caution in patients with a history of stroke, intracranial or carotid aneurysm, intracranial hemorrhage, vasospastic angina or Raynaud disease.

What if I miss a dose?

If you miss a dose, inject the missed dose as soon as possible. Then inject 1 month from the date of your last dose to get back on a monthly dosing schedule. If you have questions about your schedule, ask your healthcare provider.

How should I store this medication?

Store in the refrigerator between 36°F to 46°F (2°C to 8°C).  EMGALITY (Galcanezumab) may be stored out of refrigeration in the original carton at temperatures up to 30°C (86°F) for up to 7 days. Once stored out of refrigeration, do not place back in the refrigerator. If these conditions are exceeded, the medication must be discarded.

What are the possible side effects of using this medication?

Antibody development, injection-site reaction, hypersensitivity reaction, anaphylaxis, angioedema, skin rash.

Note this is not a complete list of side effects for EMGALITY (Galcanezumab), only common ones.