EXJADE/JADENU (Deferasirox)
EXJADE/JADENU (Deferasirox)
EXJADE/JADENU (Deferasirox)
EXJADE/JADENU (Deferasirox)
EXJADE/JADENU (Deferasirox)
EXJADE/JADENU (Deferasirox)
EXJADE/JADENU (Deferasirox)
EXJADE/JADENU (Deferasirox)
EXJADE/JADENU (Deferasirox)
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EXJADE/JADENU (Deferasirox)

Vendor
NOVARTIS PHARMACEUTICALS
Regular price
$439.99 USD
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$439.99 USD
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prescription

What is this medication?

EXJADE/JADENU (Deferasirox)
Chelating Agent

EXJADE/JADENU (Deferasirox) is an iron chelating agent indicated for the treatment of chronic iron overload due to blood transfusions in patients 2 years of age and older. 

ALERT: WARNING
EXJADE has been reported to cause renal impairment. hepatic impairment, including failure, and gastrointestinal hemorrhage which in some reported cases has been fatal.  These reactions were more frequently observed in patients with advanced age, high risk myelodysplastic syndromes (MDS), underlying renal or hepatic impairment or low platelet counts (<50 x 109 /L). EXJADE therapy requires close patient monitoring, including laboratory tests of renal and hepatic function.

What is the difference between the brands?

Jadenu is a new oral formulation of Exjade tablets for oral suspension. While Exjade is a dispersible tablet that must be mixed in liquid and taken on an empty stomach, Jadenu can be taken in a single step, with or without a light meal, simplifying administration of treatment and allows greater convenience and may be associated with fewer gastrointestinal side effects versus the original formulation. This may significantly improve compliance. In addition, the new formulation may be associated increased bioavailability.

Jadenu is 36% more bioavailable than the original formulation, Exjade. Therefore, to convert from Exjade to Jadenu the dose of Jadenu should be about 30% lower, rounded to the nearest whole tablet. To date, the new formulation of deferasirox has only been evaluated in pharmacokinetic studies in healthy volunteers. No clinical data are available yet in patients taking this formulation.

How does this medication work? 

EXJADE/JADENU (Deferasirox) is an iron chelating agent that selectively binds iron, forming a complex that is excreted primarily through the feces.

How should I take this medication? 

EXJADE
Oral:
Take 20mg/kg once daily; adjust dosage based on serum ferritin trends.

JADENU
Oral:
 Take 14mg/kg once daily; adjust dosage based on serum ferritin trends.

How to Take:
Exjade: Do not chew or swallow tablets whole.  Completely disperse tablets in water, orange juice, or apple juice (use 105 mL for total doses <1 g; 210 mL for doses ≥1 g); stir to form a fine suspension and drink entire contents. Rinse remaining residue with more fluid; drink. Avoid dispersion of tablets in milk (due to slowed dissolution) or carbonated drinks (due to foaming). Administer at same time each day on an empty stomach, at least 30 minutes before food.

Jadenu: For granules, take on an empty stomach or with a light meal at the same time each day.  For the tablets, swallow with water at the same time each day.  Take on an empty stomach or with a light meal.  The tablets can be crushed and mixed with soft food if needed.

What should I watch for while using this medication? 

Before starting EXJADE/JADENU (Deferasirox), make sure your physician is aware of any allergies or medications you currently take.  Decreased hearing and high-frequency hearing loss have been reported with using Deferasirox. Bone marrow suppression including agranulocytosis, neutropenia, thrombocytopenia, and worsening anemia have been reported (some fatal) have been reported to occur.  Deferasirox can also cause dermatologic toxicity, gastrointestinal reactions, hepatic failure, ocular disturbances and in some cases even renal failure.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Skin rash, abdominal pain, nausea, vomiting, diarrhea, proteinuria.

Note this is not a complete list of side effects for EXJADE/JADENU (Deferasirox), only common ones.