FEMARA (Letrozole)
FEMARA (Letrozole)
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FEMARA (Letrozole)

Vendor
NOVARTIS PHARMACEUTICALS
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$307.99 USD
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prescription

What is this medication? 

FEMARA (Letrozole)
Antineoplastic Agent, Aromatase Inhibitor

FEMARA (Letrozole) is indicated for the treatment of breast cancer in postmenopausal women.

How does this medication work? 

FEMARA (Letrozole) is a nonsteroidal competitive inhibitor of the aromatase enzyme system which binds to the heme group of aromatase, a cytochrome P450 enzyme which catalyzes conversion of androgens to estrogens (specifically, androstenedione to estrone and testosterone to estradiol). Inhibition of aromatase leads to a reduction in estrogen (estrone, estradiol and estrone sulfate) levels.

How should I take this medication? 

Oral: Take 2.5mg once daily.

Note: ASCO guidelines for Adjuvant Endocrine Therapy of Hormone Receptor-Positive Breast Cancer (Focused Update) recommend a maximum duration of 5 years of aromatase inhibitor therapy for postmenopausal women; aromatase inhibitors may be combined with tamoxifen for a total duration of up to 10 years of endocrine therapy.

Duration of therapy: ASCO guidelines for Adjuvant Endocrine Therapy of Hormone Receptor-Positive Breast Cancer (Focused Update) recommend a maximum duration of 5 years of aromatase inhibitor therapy for postmenopausal women; aromatase inhibitors may be combined with tamoxifen for a total duration of up to 10 years of endocrine therapy.

How to Take: Take without regard to meals.

What should I watch for while using this medication? 

Before using FEMARA (Letrozole), make sure your physician is aware of any allergies or medications you currently take, pre-existing medical conditions and activities you perform. Letrozole may cause  dizziness, fatigue, and somnolence; patients should be cautioned before performing tasks which require mental alertness.  Prolonged use of Letrozole can cause a decrease in bone mineral density. Patients on Letrozole should have their cholesterol levels monitored and may require antihyperlipidemics. Letrozole should be used with caution  in patients with hepatic impairment.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication? 

Flushing, edema, headache, dizziness, fatigue, diaphoresis, night sweats, nausea, constipation, weakness, arthralgia, arthritis, ostealgia, musculoskeletal pain, back pain, bone fracture, osteoporosis, dyspnea, cough.

Note this is not a complete list of side effects for FEMARA (Letrozole), only common ones.