HEPSERA (Adefovir Dipivoxil)
HEPSERA (Adefovir Dipivoxil)
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HEPSERA (Adefovir Dipivoxil)

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GILEAD SCIENCES
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prescription

What is this medication? 

HEPSERA (Adefovir Dipivoxil)
Antihepadenaviral, Reverse Transcriptase Inhibitor

HEPSERA (Adefovir Dipivoxil) is indicated for the treatment of chronic hepatitis B.

ALERT: WARNING
The medication can cause severe acute exacerbation of hepatitis in patients who have discontinued anti-hepatitis therapy.  Always monitor hepatic function for at least several months in patients after discontinuation of anti-hepatitis B therapy.  In patients at risk of underlying renal dysfunction, nephrotoxicity can occur and as a result careful close monitoring of rental function is a must.  Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogs alone or in combination with other antiretrovirals.

How does this medication work? 

HEPSERA (Adefovir Dipivoxil) inhibits HBV DNA polymerase (reverse transcriptase) causing DNA chain termination which stops viral replication.

How should I take this medication?

Oral: Take 10mg once daily.

How to Take: Take with or without food.

What should I watch for while using this medication? 

Before starting HEPSERA (Adefovir Dipivoxil), make sure your physician is aware of any allergies or medications you currently take.  Prior to starting Adefovir Dipivoxil, there are a number of serious warnings to be aware of including fatal lactic acidosis and severe hepatomegaly with steatosis have been reported with nucleoside analogues.  Chronic use of Adefovir Dipivoxil can result in nephrotoxicity in patients at risk of renal dysfunction or those that have underlying renal impairment.  Acute exacerbation of hepatitis B may occur upon discontinuation of Adefovir Dipivoxil resulting in the development of HIV resistance.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication? 

HEPSERA (Adefovir Dipivoxil) can cause the following severe side effects: hepatitis, nephrotoxicity, resistant form of HIV, lactic acidosis.  The most common side effects are weakness, headache, stomach pain, nausea, flatulence, diarrhea, indigestion and changes in the way the kidneys work.  Additional side effects in liver transplant patients with chronic hepatitis B are vomiting, rash and itching.

Note this is not a complete list of side effects for HEPSERA (Adefovir Dipivoxil), only common ones.