IBSRELA (Tenapanor)

IBSRELA (Tenapanor)

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What is this medication?

IBSRELA (Tenapanor)
Sodium/Hydrogen Exchanger 3 (NHE3) Inhibitor

IBSRELA (Tenapanor) is indicated for the treatment of irritable bowel syndrome with constipation.

How does this medication work? 

IBSRELA (Tenapanor) is a sodium/hydrogen exchanger 3 inhibitor, which acts locally to reduce sodium absorption from the small intestine and colon.  Reduced sodium absorption causes an increase in water left in the intestinal lumen, accelerating intestinal peristalsis and soften the stool.  Tenapanor has also been shown to help reduce intestinal permeability and abdominal pain.

How should I take this medication?

Oral: Take 50mg twice daily.

How to Take: Take 5 to 10 minutes prior to breakfast or the first meal of the day and 5 to 10 minutes prior to dinner.  Swallow whole; do not crush or chew.

What should I watch for while using this medication? 

Before starting IBSRELA (Tenapanor), make sure your physician is aware of any allergies or medications you currently take, and current medical conditions.  Tenapanor has been associated with diarrhea, bloating, flatulence and dizziness.  Tenapanor should be used with caution in patients with renal impairment because of the risk of hyperkalemia.

What if I miss a dose?

If a dose is missed, skip the missed dose and administer the next dose at the regular time. Do not administer 2 doses at the same time.

How should I store this medication?

Keep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Diarrhea, dizziness, bloating, flatulence.

Note this is not a complete list of side effects for IBSRELA (Tenapanor), only common ones.