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  • Load image into Gallery viewer, Imipramine
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What is this medication?

TOFRANIL (Imipramine)
Antidepressant, Tricyclic (Tertiary Amine)

TOFRANIL (Imipramine) in indicated for treatment of major depressive disorder; childhood enuresis.

Antidepressants increased the risk compared with placebo of suicidal thinking and behavior (suicidality) in short-term studies in children, adolescents, and young adults with major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of imipramine or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared with placebo in adults older than 24 years; there was a reduction in risk with antidepressants compared with placebo in adults 65 years and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the health care provider. Imipramine is not approved for use in pediatric patients except for patients with nocturnal enuresis.

How does this medication work?

TOFRANIL (Imipramine) increases the synaptic concentration of serotonin and/or norepinephrine in the central nervous system by inhibition of its reuptake by the presynaptic neuronal membrane. Additional receptor effects have been found including desensitization of adenyl cyclase, down regulation of beta-adrenergic receptors, and down regulation of serotonin receptors.

How should I take this medication?

 Take 25mg to 300mg once daily
 given in divided doses or as a single bedtime dose.

Enuresis:  6 to <12 years old :Take 10mg once daily at bedtime to a maximum of the lesser of 2.5mg/kg/day or 50mg/day.

 ≥12 years old: Take 10mg once daily at bedtime to a maximum of 75mg/day.

How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same times each day unless otherwise directed. Generally taken 1-3 hour prior to bed to minimize daytime drowsiness.

You Need to Avoid: Do not stop this medication without tapering dose down over time to prevent withdrawal symptoms (nausea, diarrhea, sweating, headaches, agitation, insomnia, anxiety, tremor, vertigo, dizziness, tingling in extremities). Tolerance to sedation may develop however caution operating heavy machinery or driving if feeling impaired. May increase the central nervous system depressant effects of alcohol so caution if alcohol is to be consumed.

What should I watch for while using this medication?

Before starting TOFRANIL (Imipramine) make sure your physician is aware of any allergies, medications you currently take, if you have alcohol use disorder, cardiovascular disease, diabetes, hepatic impairment, mania/hypomania, myasthenia gravis, narrow angle glaucoma, renal impairment, a seizure disorder, a history of suicidal ideation, are pregnant, or breastfeeding.  Imipramine, Tofranil use has been associated with potentially serious adverse reactions including anticholinergic effects, CNS depression, increased risk of fracture, hematologic reactions, orthostatic hypotension, photosensitization, and serotonin syndrome.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose.  Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Cardiac arrhythmia, cardiac failure, cerebrovascular accident, ECG changes, heart block, hypertension, myocardial infarction, orthostatic hypotension, palpitations, tachycardia, agitation, anxiety, ataxia, confusion, delusions, disorientation, dizziness, drowsiness, EEG pattern changes, extrapyramidal reaction, falling, fatigue, hallucination, headache, hypomania, insomnia, nightmares, numbness, paresthesia, peripheral neuropathy, psychosis, restlessness, seizure, taste disorder, tingling sensation, alopecia, diaphoresis, pruritus, skin photosensitivity, skin rash, urticaria, decreased libido, decreased serum glucose, galactorrhea, gynecomastia, increased libido, increased serum glucose, SIADH, weight gain, weight loss, abdominal cramps, anorexia, constipation, diarrhea, epigastric distress, intestinal obstruction, melanoglossia, nausea, stomatitis, sublingual adenitis, vomiting, xerostomia, breast hypertrophy, impotence, testicular swelling, urinary hesitancy, urinary retention, urinary tract dilation, agranulocytosis, eosinophilia, petechia, purpura, thrombocytopenia, cholestatic jaundice, increased serum transaminases, hypersensitivity (eg, drug fever, edema), tremor, weakness, accommodation disturbance, angle-closure glaucoma, blurred vision, mydriasis, tinnitus.

Note this is not a complete list of side effects for TOFRANIL (Imipramine), only common ones.