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What is this medication?

CAMPTOSAR (Irinotecan)
Antineoplastic Agent

CAMPTOSAR (Irinotecan) can cause both early and late forms of diarrhea accompanied by cholinergic symptoms.  Late diarrhea can be life-threatening and should be treated promptly and monitored carefully.   Irinotecan can also cause severe bone marrow suppression.

How does this medication work? 

CAMPTOSAR (Irinotecan) prevents the relegation of cleaved DNA which causes an accumulation of cleavable complexes and double-strand DNA break leading to the termination in cell replication.

How should I take this medication? 

IV: Administer by intravenous infusion, usually over 90 minutes.

Note: a reduction in the starting dose by at least one dose level should be considered for prior pelvic/abdominal radiotherapy, performance status of 2, or known homozygosity for UGT1A1*28 allele (subsequent dosing/adjustments should be based on individual tolerance).

Irinotecan (conventional) and irinotecan (liposomal) are NOT interchangeable. Dosing differs between formulations; verify intended product and dose prior to preparation and administration.

What should I watch for while using this medication? 

Before starting CAMPTOSAR (Irinotecan), make sure your physician is aware of any allergies or medications you currently take, and activities you perform.  Irinotecan has been associated with serious adverse effects such as severe myelosuppression, diarrhea, extravasation, gastrointestinal, pulmonary toxicity, renal toxicity and thromboembolism.  Irinotecan should not be used in patients with a bowel obstruction, and with caution in those with hepatic impairment.   Elderly, patients > 65 are at a greater risk for early and late diarrhea. 

What if I miss a dose?

It is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor to establish a new dosing schedule.

How should I store this medication?

Store at room temperature 15°C to 30°C (59° to 86°F). Keep the vial in the carton until the time of use to protect from light. 

What are the possible side effects of using this medication?

Vasodilation, cholinergic syndrome which includes diaphoresis, flushing, increased peristalsis, lacrimation, miosis and rhinitis, pain, dizziness, insomnia, headache, alopecia, weight loss, dehydration, diarrhea, nausea, abdominal pain, vomiting, anorexia, constipation, flatulence, anemia, leukopenia, neutropenia, thrombocytopenia, elevated liver enzymes and bilirubin, infection, muscle weakness and pain, dyspnea, cough, fever.

Note this is not a complete list of side effects for CAMPTOSAR (Irinotecan), only common ones.