KESIMPTA (Ofatumumab)

KESIMPTA (Ofatumumab)

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prescription refrigerated

What is this medication? 

KESIMPTA (Ofatumumab)
Anti-CD20 Monoclonal Antibody, Antineoplastic Agent

KESIMPTA (Ofatumumab) is a CD20-directed cytolytic antibody indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.

How does this medication work? 

KESIMPTA (Ofatumumab) is a monoclonal antibody which binds specifically the extracellular loops of the CD20 molecule resulting in potent complement-dependent cell lysis and antibody-dependent cell-mediated toxicity in cells that overexpress CD20.

How should I take this medication? 

SQ: Inject 20 mg subcutaneously once weekly for 3 doses (weeks 0, 1, and 2); maintenance: 20 mg once monthly starting at week 4.

How to Take: Administer by subcutaneous injection in the abdomen, thigh, or outer upper arm. Avoid moles, scars, stretch marks, or areas where the skin is tender, bruised, red, scaly, or hard. The first injection should be performed under the guidance of a health care professional.
Sensoready pens and syringes are for one-time use only; discard after use.

What should I watch for while using this medication? 

Before starting KESIMPTA (Ofatumumab) make sure your physician is aware of any allergies or medications you currently take.  Do not use Ofatumumab if you have an active infection.  It is not recommended to be vaccinated with live-attenuated or live vaccines during treatment. Ofatumumab has been associated with serious opportunistic infections. Monitor the level of immunoglobulins at the beginning, during, and after discontinuation of treatment with Ofatumumab until B-cell repletion.

What if I miss a dose?

If you miss an injection at Week 0, 1, or 2, talk to your doctor. If you miss a monthly injection, take it as soon as possible without waiting until the next scheduled dose. After that, take your injections a month apart.

How should I store this medication?

Store in the refrigerator at 2ºC to 8ºC (36ºF to 46ºF). Keep product in the original carton to protect from light until the time of use. Do not freeze.

What are the possible side effects of using this medication?

Skin rash, diarrhea, nausea, anemia, neutropenia, infection, fatigue, bronchitis, cough, dyspnea, pneumonia, upper respiratory tract infection, fever, infusion related reaction, headache, hypertension, hypotension, peripheral edema, tachycardia, hyperhidrosis, urticaria, hypogammaglobulinemia, herpes zoster infection, influenza, sepsis, chills, headache, insomnia, back pain, muscle spasm, nasopharyngitis, sinusitis, urinary tract infection, decreased serum immunoglobulins, back pain.

Note this is not a complete list of side effects for KESIMPTA (Ofatumumab), only common ones.