LONSURF (Trifluridine/Tipiracil)
LONSURF (Trifluridine/Tipiracil)
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LONSURF (Trifluridine/Tipiracil)

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What is this medication?

LONSURF (Trifluridine/Tipiracil)
Antineoplastic Agent, Antimetabolite; (Pyrimidine Analog)Thymidine Phosphorylase Inhibitor

LONSURF is a combination of Trifluridine, a nucleoside metabolic inhibitor, and Tipiracil, a thymidine phosphorylase inhibitor, indicated for the treatment of patients with metastatic colorectal cancer.

How does this medication work? 

Trifluridine is a thymidine-based nucleic acid analogue; the triphosphate form of Trifluridine is incorporated into DNA which interferes with DNA synthesis and inhibits cell proliferation.

Tipiracil is a potent thymidine phosphorylase inhibitor which prevents the rapid degradation of Trifluridine, allowing for increased Trifluridine exposure.

How should I take this medication? 

Oral: Take 35 mg/m2 /dose orally twice daily on Days 1 through 5 and Days 8 through 12 of each 28-day cycle. 

How to Take: Take within 1 hour after completion of breakfast and dinner.

What should I watch for while using this medication? 

Before starting LONSURF (Trifluridine/Tipiracil), make sure your physician is aware of any allergies or medications you currently take. Trifluridine/Tipiracil can cause severe myelosuppression which increases the risk of experiencing an infection.  It is recommended to obtain a complete blood count prior to and on Day 15 of each cycle. Reduce the dose of Trifluridine/Tipiracil if required.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Fatigue, nausea, vomiting, abdominal pain, decrease in appetite, fever and diarrhea.

Note this is not a complete list of side effects for LONSURF (Trifluridine/Tipiracil), only common ones.