MOVANTIK (Naloxegol)
MOVANTIK (Naloxegol)
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MOVANTIK (Naloxegol)

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What is this medication?

MOVANTIK (Naloxegol)
Gastrointestinal Agent, MiscellaneousOpioid Antagonist, Peripherally-Acting

MOVANTIK (Naloxegol) is indicated for the management of opioid-induced constipation.

How does this medication work? 

MOVANTIK (Naloxegol) is comprised of naloxone conjugated with a polyethylene glycol polymer.  Naloxone is a mu-opioid receptor antagonist, and the polyethylene glycol polymer limits its ability to cross the blood-brain barrier. When administered at the recommended dose, naloxegol functions peripherally in tissues such as the GI tract, thereby decreasing the constipation associated with opioids.

How should I take this medication?

Oral: Take 25 mg once daily. If not tolerated, reduce dose to 12.5 mg once daily. Discontinue treatment if opioid pain medication is discontinued.

How to Take: Discontinue all maintenance laxative therapy prior to use; may reintroduce laxatives as needed if suboptimal response to naloxegol after 3 days. Alteration in analgesic dosing regimen prior to initiating naloxegol is not required. Administer on an empty stomach at least 1 hour prior to or 2 hours after the first meal of the day. Swallow tablets whole and do not chew.

You Need to Avoid: Avoid consumption of grapefruit or grapefruit juice during treatment.

What should I watch for while using this medication? 

Before starting MOVANTIK (Naloxegol), make sure your physician is aware of any allergies or medications you currently take, if you have a known or suspected GI obstruction, hepatic impairment, renal impairment, are pregnant, or breastfeeding. MOVANTIK (Naloxegol) use has been associated with rare but serious adverse events such as gastrointestinal effects, gastrointestinal perforation, and opioid withdrawal symptoms (hyperhidrosis, chills, diarrhea, abdominal pain, anxiety, irritability, yawning).

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose.  Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Abdominal pain, headache, opioid withdrawal syndrome, hyperhidrosis, diarrhea, nausea, flatulence, vomiting.

Note this is not a complete list of side effects for MOVANTIK (Naloxegol), only common ones.