NEXAVAR (Sorafenib)

NEXAVAR (Sorafenib)

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What is this medication?

NEXAVAR (Sorafenib)
AntineoplastiAgent, Tyrosine Kinase InhibitorVascular Endothelial Growth Factor (VEGF) Inhibitor

NEXAVAR (Sorafenib) is indicated for the treatment of hepatocellular carcinoma; Renal cell carcinoma, advanced; Thyroid carcinoma, differentiated.

How does this medication work?

Sorafenib is a multikinase inhibitor that inhibits tumor growth and angiogenesis by inhibiting intracellular Raf kinases (CRAF, BRAF, and mutant BRAF), and cell surface kinase receptors (VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-beta, cKIT, FLT-3, RET, and RET/PTC).

How should I take this medication? 

Oral: Take 400 mg twice daily until no longer clinically benefiting or until unacceptable toxicity occurs.

How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same times each day unless otherwise directed. Administer without food (at least 1 hour before or 2 hours after a meal).

What should I watch for while using this medication? 

Before starting NEXAVAR (Sorafenib) make sure your physician is aware of any allergies or medications you currently take, if you are pregnant, or breastfeeding. Sorafenib use has been associated with rare but serious adverse events such as bleeding, cardiovascular events, dermatologic toxicity, GI perforation, hepatotoxicity, hypertension, QT prolongation, thyroid impairment, and wound healing complications.

Temporarily withhold Sorafenib for at least 10 days prior to elective surgery; do not administer Sorafenib for at least 2 weeks following major surgery and until adequate wound healing.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication? 

NEXAVAR (Sorafenib) can cause serious side effects including a decrease in myocardial blood circulation resulting in a heart attack and/or heart failure.  Sorafenib can increase the risk of bleeding.  Look for signs of bleeding during treatment such as coffee ground vomit appearance, pink or brown urine, red or black stools, blood in the sputum, heavier than normal menstrual cycle, unusual vaginal bleeding, frequent nose bleeds and bruising.  Sorafenib can cause hypertension, monitoring your blood pressure weekly and treat if required.  Sorafenib has been associated with several dermatological conditions including skin rash, pain or swelling, blistering and peeling of your skin .  An opening in the wall of your stomach or intestines (gastrointestinal perforation) has occurred with using Sorafenib, monitor for signs of fever, nausea, vomiting or severe stomach (abdominal) pain.  Sorafenib may cause changes in the electrical activity of your heart called QT prolongation. Sorafenib may cause liver problems that may lead to liver failure and death. Your healthcare provider will do blood tests to check your liver function regularly during your treatment.

Note this is not a complete list of side effects for NEXAVAR (Sorafenib), only common ones.