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What is this medication?

Nilutamide, Nilandron(US)/Anandron(CDN)
Antineoplastic, Antiandrogen

Brand Name US: Nilandron
Canadian Equivalent: Anandron

Nilutamide, Nilandron/Anandron is indicated for treatment of prostate cancer.

“Alert: US Warning
Interstitial pneumonitis, including pulmonary fibrosis has been reported rarely post-marketing.  Symptoms included exertional dyspnea, cough, chest pain, and fever. X-rays showed interstitial or alveolo-interstitial changes, and pulmonary function tests revealed a restrictive pattern with decreased diffusing capacity of lungs for carbon monoxide. Most cases occurred within the first 3 months of treatment with nilutamide, and most reversed with discontinuation of therapy.”

How does this medication work?

Nilutamide is a nonsteroidal antiandrogen which blocks testosterone effects at the androgen receptor level, preventing androgen response.

How should I take this medication? 

Usual (Oral): 300 mg once daily (starting the same day or day after surgical castration) for 30 days, followed by 150 mg once daily. Consider therapy discontinuation in patients with evidence of disease progression.

What should I watch for while using this medication? 

Before using Nilutamide, Nilandron/Anandron make sure your physician is aware of any allergies or medications you currently take, pre-existing medical conditions and activities you perform.  Patients receiving nilutamide may experience aplastic anemia because of a suppression in their testosterone levels; should monitor CBC periodically. Interstitial pneumonitis has been reported in patients receiving nilutamide.  Discontinue Nilutamide, Nilandron/Anandron immediately if signs and/or symptoms of interstitial pneumonitis are observed until a causal effect can be ruled out.  There has been a delay in adapting to dark conditions ranging from a few seconds to a few minutes after passing from a light to a dark area. This may not abate with continued treatment although may be alleviated by wearing tinted sunglasses. Caution patients who experience adaptation delay about driving at night or through tunnels.  Prolonged use of antiandrogen therapy is associated with decreased bone mineral density and an increased risk of osteoporosis and fracture. Evaluate risk carefully before initiating therapy.  Hyperglycemia has been observed; use with caution in diabetic patients and monitor for loss of glucose control.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication? 

Hot flash, nocturnal amblyopia, hypertension, cardiac failure, angina pectoris, edema, syncope, dizziness, paresthesia, malaise, nervousness, pruritus, hyperglycemia, increased haptoglobin, weight loss, nausea, constipation, diarrhea, gastrointestinal hemorrhage, melena, xerostomia, leukopenia, increased serum ALT, increased serum AST, increased serum alkaline phosphatase, arthritis, visual disturbance, cataract, photophobia, increased blood urea nitrogen, increased serum creatinine, dyspnea, cough, interstitial pneumonitis, rhinitis, alcohol intolerance

Note this is not a complete list of side effects, only the most common.