NITROLINGUAL (Nitroglycerin)

NITROLINGUAL (Nitroglycerin)

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What is this medication?

Nitroglycerin/Glyceryl Trinitrate, Nitrolingual/Nitrostat
Antianginal Agent; Vasodilator

Nitroglycerin/Glyceryl Trinitrate (Sublingual), Nitrolingual/Nitrostat is officially indicated for coronary artery disease/angina, or chronic anal fissures.  It is also prescribed off-label for acute decompensated heart failure, esophageal spastic disorders, gastroesophageal variceal hemorrhage, and uterine relaxation for inversion. (may be used for conditions not listed)

How does this medication work? 

Nitroglycerin/Glyceryl Trinitrate (Sublingual), Nitrolingual/Nitrostat forms nitric acid which increases cGMP which dephosphorylates myosin light chains in smooth muscle resulting in their relaxation.  This results in vasodilation of peripheral veins and arteries with more effect on the veins. Reduces oxygen demand of heart by decreasing the preload and modestly reducing afterload of left ventricle.  It also increased blood flow to ischemic areas of heart via action of coronary arteries.  If used rectally for fissures it decreases sphincter tone and intra-anal pressure.

How should I take this medication? 

Use one spray or place one tablet under the tongue as needed for chest pain.  Suggest sitting before dosage due to potential for dizziness from decreased blood pressure.  If no relief within 5 minutes, try another dosage and if no relief after another 5 minutes repeat dosage one more time and call and ambulance.

How to Take: Follow instructions provided by physician/pharmacy label, store at room temperature, make sure to prime bottle of solution if has not been used recently.

You Need to Avoid: Do not chew or swallow sublingual tablets, do not shake spray before use, do not use with erectile dysfunction medications

What should I watch for while using this medication? 

Before starting Nitroglycerin/Glyceryl Trinitrate (Sublingual), Nitrolingual/Nitrostat make sure your physician is aware of any allergies, medications (medications that can be used for erectile dysfunction especially) you currently take, if you have hypertrophic cardiomyopathy, closed angle glaucoma, if you are pregnant, or breastfeeding.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Do not place spray in hot water or near radiators, stoves or other sources of heat. Keep the bottle tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Headache, hypotension, syncope (fainting), dizziness 

Note this is not a complete list of side effects.