ODEFSEY (Emtricitabine/Rilpivirine/ Tenofovir Alafenammide)

ODEFSEY (Emtricitabine/Rilpivirine/ Tenofovir Alafenammide)

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What is this medication?

Rilpivirine+Emtricitabine+Tenofovir Alafenamide, Odefsey
Antiretroviral, Reverse Transcriptase Inhibitor, Non-nucleoside (Anti-HIV)

“ALERT: US Boxed Warning

​HIV-1 and hepatitis B coinfection:
Severe acute exacerbations of hepatitis B have been reported in patients who are coinfected with HIV-1 and hepatitis B virus (HBV) and have discontinued products containing emtricitabine and/or tenofovir disoproxil fumarate, and may occur with discontinuation of emtricitabine/rilpivirine/tenofovir alafenamide.

Hepatic function should be monitored closely with both clinical and laboratory follow-up for at least several months in patients who are coinfected with HIV-1 and HBV and discontinue emtricitabine/rilpivirine/tenofovir alafenamide. If appropriate, anti-hepatitis B therapy may be warranted.”

How does this medication work?

Rilpivirine binds to reverse transcriptase and does not require intracellular phosphorylation for antiviral activity. Emtricitabine is a cytosine analogue and tenofovir alafenamide is converted intracellularly to tenofovir (adenosine nucleotide analog) and subsequently phosphorylated by cellular kinases to the active moiety, tenofovir diphosphate. Emtricitabine and tenofovir alafenamide interfere with HIV viral RNA-dependent DNA polymerase activities resulting in inhibition of viral replication.

How should I take this medication?

Oral: One tablet (emtricitabine 200 mg/rilpivirine 25 mg/tenofovir alafenamide 25 mg) once daily.

How to Take: Take with food at the same time each day

What should I watch for while using this medication?

Before starting Rilpivirine+Emtricitabine+Tenofovir Alafenamide, Odefsey make sure your physician is aware of any allergies or medications you currently take.  Patients have been known to experience depressive disorders, hepatotoxicity, hypersensitivity reactions, immune reconstitution syndrome, lactic acidosis, hepatomegaly, QT prolongation and renal toxicity while taking Rilpivirine+Emtricitabine+Tenofovir Alafenamide, Odefsey.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose.  Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Elevated bilirubin, headache, abnormal dreams, fatigue, dizziness, nausea, diarrhea, depression, drowsiness, increased cholesterol, decreased bone mineral density.

Note this is not a complete list of side effects, only common ones.