Pentoxifylline SR

Pentoxifylline SR

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What is this medication? 

Pentoxifylline, Trental/Pentoxil
Blood Rheology Modifier; Blood Viscosity Reducer 

Pentoxifylline, Trental/Pentoxil is indicated for management of chronic occlusive peripheral vascular disorders.

How does this medication work? 

Pentoxifylline, Trental/Pentoxil improves peripheral blood flow and enhances peripheral tissue oxygenation.  The exact mechanism of action is unknown, but several mechanisms may be involved: a reduction in blood viscosity, inhibition of platelet aggregation, improves erythrocyte flexibility, decreases fibrinogen concentration, and alters granulocyte function.  Underlying mechanisms may involve inhibition of phosphodiesterase resulting in increased intracellular cAMP levels, increased vascular prostacyclin, decreased thromboxane A2 and phosphorylation of red blood cell membrane proteins.

How should I take this medication? 

Oral: Initially 400mg twice daily after meals.  Usual maintenance dose is 400mg two or three times daily.  Maximum daily dose is 1200mg daily.

How to Take:  Swallow whole, do not split and/or crush the tablets as they are sustained release.  Give with or after meals to less gastric irritation.  

What should I watch for while using this medication? 

Do not use in patients with hypersensitivity or intolerant to pentoxifylline or other xanthines (i.e. caffeine, theophylline, theobromine)

Do not use in severe renal and liver impairment

Do not use in cases of an acute myocardial infarction, severe coronary artery disease when myocardial stimulation might prove harmful, peptic ulcers (current or recent)

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication? 

Well tolerated, most side effects are transient and mild to moderate in nature.  The most common side effects include:

Gastrointestinal: Nausea (2%), vomiting (1%)

Other Common Side Effects of Pentoxifylline, Trental/Pentoxil: Chest pain, dizziness, headache, nausea, and abdominal discomfort.  Report any chest pain; the other side effects are transient in nature; dose reduction may be required if the symptoms persist. 

Stop taking this medication and contact your doctor if you experience any chest pain.