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What is this medication? 

Pimozide, Orap
First Generation (Typical) Antipsychotic

Pimozide, Orap is indicated for management of tourette disorder

How does this medication work? 

Pimozide, Orap Pimozide is a potent centrally-acting dopamine-receptor antagonist resulting in its characteristic neuroleptic effects.

How should I take this medication? 

Oral: Initial: 1 to 2 mg/day in divided doses, then increase dosage as needed every other day; maximum dose: 10 mg/day or 0.2 mg/kg/day (whichever is less)

How to Take: May be administered without regard to meals but is preferable to administer dose at bedtime.  If therapy requires exceeding dose of 4 mg/day, CYP2D6 geno-/phenotyping should be performed as CYP2D6 poor metabolizers must be tirtrated more slowly and should not exceed 4 mg/day.

You Need to Avoid:  Significant drug interactions exist, requiring dose/frequency adjustment or avoidance so avoid starting any new medications without consulting prescriber.   Do not stop this medication suddenly, make sure your physician is aware and can create a tapering schedule so you can come off slowly and prevent any withdrawal symptoms.

What should I watch for while using this medication? 

starting Pimozide, Orap make sure your physician is aware of any allergies or medications you currently take, if you have cardiovascular disease, dementia, a depressive disorder, Parkinson disease, pheochromocytoma, hepatic impairment, renal impairment, a seizure disorder, are a poor CYP2D6 metabolizer, are pregnant, or breastfeeding. Pimozide, Orap use has been associated with rare but serious adverse events such as altered cardiac conduction, QT prolongation, anticholinergic effects, blood dyscrasias, CNS depression, esophageal dysmotility, aspiration, extrapyramidal symptoms, hyperprolactinemia, neuroleptic malignant syndrome, and temperature dysregulation.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication? 

Sedation, akathisia, drowsiness, behavioral changes, hypertonia, xerostomia, constipation, impotence, akinesia, weakness, decreased accommodation, visual disturbance

Note this is not a complete list of side effects, only the most common