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What is this medication?

Prochlorperazine, Compazine
Antiemetic, First Generation (Typical) Antipsychotic

Prochlorperazine, Compazine is indicated for nausea and/or vomiting.

Elderly patients suffering from dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.  Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. Prochlorperazine is not approved for the treatment of patients with dementia-related psychosis.

How does this medication work?

Prochlorperazine is a piperazine phenothiazine antipsychotic which blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain, including the chemoreceptor trigger zone; exhibits a strong alpha-adrenergic and anticholinergic blocking effect and depresses the release of hypothalamic and hypophyseal hormones; believed to depress the reticular activating system, thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone and emesis.

How should I take this medication?

Oral: Take 5mg to 10mg every 6 to 8 hours as needed.  Maximum daily dose is 40mg.

What should I watch for while using this medication?

Before using a Prochlorperazine, Compazine make sure your physician is aware of any allergies or medications you currently take, pre-existing medical conditions and activities you perform.
Prochlorperazine, Compazine may alter cardiac conduction, cause anticholinergic side effects such as constipation, xerostomia, blurred vision, urinary retention and should be used with caution in patients with decreased gastrointestinal motility, paralytic ileus, urinary retention, BPH, xerostomia, or visual problems. Prochlorperazine, Compazine has been reported to cause leukopenia, neutropenia, and agranulocytosis. Prochlorperazine, Compazine may cause extrapyramidal symptoms including pseudoparkinsonism, acute dystonic reactions, akathisia, and tardive dyskinesia. Prochlorperazine, Compazine use is associated with increased prolactin levels, hypotension, neuroleptic malignant syndrome, and temperature regulation.  Prochlorperazine should be used with caution in patients with cardiovascular disease, hepatic and/or renal impairment and risk of seizures.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose.  Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

The frequency and incidence of side effects is not well defined but do include:

ECG abnormality, hypotension, peripheral edema, agitation, altered cerebrospinal proteins, catatonia, cerebral edema, coma, decreased cough reflex, disruption of body temperature regulation, dizziness, drowsiness, dystonia (carpopedal spasm, protrusion of tongue, torticollis, trismus), extrapyramidal reaction (akathisia, dystonias, hyperreflexia, pseudoparkinsonism, tardive dyskinesia), headache, hyperpyrexia, insomnia, jitteriness, neuroleptic malignant syndrome (NMS), opisthotonos, restlessness, seizure, contact dermatitis, diaphoresis, erythema, eczema, exfoliative dermatitis, pruritus, skin photosensitivity, skin changes, skin pigmentation, urticaria, amenorrhea, change in libido, galactorrhea, gynecomastia, glycosuria, hyperglycemia, hypoglycemia, menstrual disease, weight gain, atony of colon, cholestasis, increased appetite, constipation, intestinal obstruction, nausea, obstipation, vomiting, xerostomia, ejaculatory disorder, impotence, lactation, priapism, urinary retention, agranulocytosis, aplastic anemia, eosinophilia, hemolytic anemia, immune thrombocytopenia, leukopenia, pancytopenia, cholestatic jaundice, hepatotoxicity, anaphylactoid reaction, angioedema, hypersensitivity reaction, infection, lupus-like syndrome, tremor, blurred vision, cataract, epithelial keratopathy, corneal deposits, miosis, mydriasis, oculogyric crisis, retinitis pigmentosa, asphyxia, asthma, laryngeal edema, nasal congestion, fever.