PULMOZYME (Dornase Alfa)

PULMOZYME (Dornase Alfa)

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prescription refrigerated

What is this medication? 

PULMOZYME (Dornase Alfa)
Recombinant Human Deoxyribonuclease; Mucolytic Agent

PULMOZYME (Dornase Alfa) is a recombinant DNase enzyme indicated in conjunction with standard therapies for the management of cystic fibrosis (CF) to improve pulmonary function.

How does this medication work?

PULMOZYME (Dornase Alfa) is a recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA from the neutrophils and reducing mucous viscosity, and further preventing airway infections and damage to the lung parenchyma.

How should I take this medication? 

Inhalation: Inhale the contents of a 2.5mg single-use ampule using a nebulizer once to twice daily.

What should I watch for while using this medication? 

Before starting PULMOZYME (Dornase Alfa), make sure your physician is aware of any allergies or medications you currently take.   Replace the handset after 90 uses when administering Dornase Alfa with the eRapid Nebulizer System.  The eRapid Nebulizer System should only be used by adults and children who can use a mouthpiece, and not by younger children who need a mask to take Dornase Alfa. 

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Store PULMOZYME (Dornase Alfa) in their protective foil pouch under refrigeration and protected from light. Refrigerate ampules during transport and do not expose to room temperatures for a total time of 24 hours. Each ampule should be squeezed prior to use in order to check for leaks. Discard ampules if the solution is cloudy or discolored. Once opened, the entire contents of the ampule must be used or discarded.

What are the possible side effects of using this medication? 

Voice alteration, pharyngitis, rash, laryngitis, chest pain, conjunctivitis, rhinitis, fever, and dyspnea.

Note this is not a complete list of side effects for PULMOZYME (Dornase Alfa), only common ones.