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What is this medication?

Phosphate Binder

RENVELA/RENAGEL (Sevelamer) is indicated for control of serum phosphorous.

How does this medication work? 

RENVELA/RENAGEL (Sevelamer) binds phosphate within the intestinal tract, limiting absorption and decreasing serum phosphate concentrations without altering calcium, aluminum, or bicarbonate concentrations.

How should I take this medication? 

Control of serum phosphorous: Oral: 800 to 1,600 mg 3 times daily with meals; the initial dose may be based on serum phosphorous levels; maximum dose studied was equivalent to 13 g/day sevelamer hydrochloride or 14 g/day sevelamer carbonate.

Note: The dosing of sevelamer carbonate and sevelamer hydrochloride are similar; when switching from one product to another, the same dose (on a mg per mg basis) should be utilized.

How to Take: Administer with meals. May prepare an oral suspension in water using the directed amount of water appropriate for the packet size or may premix the entire content of the packet with a small amount of food or beverage (do not heat or add to heated foods or liquids). Preparations should be consumed immediately or within 30 minutes. Oral suspension in water may need to be resuspended immediately before drinking. Swallow tablets whole; do not crush, chew, or break.  May cause reductions in vitamin D, E, K, or folic acid absorption so consider vitamin supplementation.

You Need to Avoid:  Significant drug interactions exist, requiring dose/frequency adjustment or avoidance so avoid starting any new medications without consulting prescriber.

What should I watch for while using this medication?

Before starting RENVELA/RENAGEL (Sevelamer) make sure your physician is aware of any allergies or medications you currently take, if you have a bowel obstruction, an active mucosal injury, hypophosphatemia, other gastrointestinal disease, are pregnant, or breastfeeding. RENVELA/RENAGEL (Sevelamer) use has been associated with rare but serious adverse events such as bowel obstruction, GI ulcers, colitis, necrosis, perforation, dysphagia and esophageal tablet retention.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication? 

Metabolic acidosis, diarrhea, dyspepsia, nausea, vomiting, abdominal pain, constipation, flatulence, peritonitis

Note this is not a complete list of side effects for RENVELA/RENAGEL (Sevelamer), only the most common.