ROFACT (Rifampin)
ROFACT (Rifampin)
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ROFACT (Rifampin)

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What is this medication?

Rifampin, Rofact (CDN)/Rifadin (US/CDN)
Antitubercular AgentRifamycin

Rifampin, Rofact/Rifadin is indicated for treatment of tuberculosis; meningococcal prophylaxis

How does this medication work?

Rifampin, Rofact/Rifadin inhibits bacterial RNA synthesis by binding to the beta subunit of DNA-dependent RNA polymerase, blocking RNA transcription.

How should I take this medication?

Oral: 10 mg/kg (maximum dose: 600 mg) once or twice a day

How to Take: Administer on an empty stomach with a glass of water (ie, 1 hour prior to, or 2 hours after meals or antacids) to increase total absorption (food may delay and reduce the amount of rifampin absorbed). The compounded oral suspension must be shaken well before using. May mix contents of capsule with applesauce or jelly.  Administer IV preparation by slow IV infusion over 30 minutes to 3 hours at a final concentration not to exceed 6 mg/mL.

You Need to Avoid: Do not wear soft contact lenses during therapy since permanent staining may occur.    Do not administer intramuscularly or subcutaneously. Avoid extravasation.

What should I watch for while using this medication?

Before starting Rifampin, Rofact/Rifadin make sure your physician is aware of any allergies or medications you currently take, if you have a history of alcoholism, diabetes mellitus, hepatic impairment, meningococcal disease, porphyria, are pregnant, or breastfeeding. Rifampin, Rofact/Rifadin use has been associated with rare but serious adverse events such as coagulopathy, dermatologic reactions, flu-like syndrome, hematologic effects, hepatotoxicity, hypersensitivity reactions, and bacterial superinfection.
The teeth, urine, feces, saliva, sweat, and tears may be discolored (yellow, orange, red, or brown) from use of this medication.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose.  Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Decreased blood pressure, flushing, shock, vasculitis, ataxia, behavioral changes, confusion, dizziness, drowsiness, fatigue, headache, lack of concentration, myasthenia, numbness, peripheral pain, sore mouth, erythema multiforme, pemphigoid reaction, pruritus, skin rash, urticaria, adrenocortical insufficiency, menstrual disease, abdominal cramps, anorexia, diarrhea, epigastric discomfort, flatulence, glossalgia, heartburn, nausea, staining of tooth, vomiting, hemoglobinuria, hematuria, decreased hemoglobin, disorder of hemostatic components of blood (vitamin K-dependent), disseminated intravascular coagulation, eosinophilia, hemolysis, hemolytic anemia, hemorrhage, leukopenia, thrombocytopenia (especially with high-dose therapy), abnormal hepatic function tests, hepatic insufficiency, hyperbilirubinemia, jaundice, hypersensitivity reaction, myopathy, conjunctivitis, visual disturbance, acute renal failure, interstitial nephritis, renal insufficiency, renal tubular necrosis, dyspnea, flu-like symptoms, wheezing, fever

Note the frequency of side effects have not been defined.