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What is this medication?

Rosiglitazone, Avandia
Antidiabetic Agent; Thiazolidinedione

Officially indicated for treatment of Diabetes Mellitus Type 2.

“ALERT: US Boxed Warning

Congestive heart failure:
Thiazolidinediones, including rosiglitazone, cause or exacerbate congestive heart failure (CHF) in some patients. After initiation of rosiglitazone and after dose increases, observe patients carefully for signs and symptoms of heart failure (including excessive, rapid weight gain; dyspnea; and/or edema). If these signs and symptoms develop, manage the heart failure according to current standards of care. Furthermore, consider discontinuation or dose reduction of rosiglitazone.

Rosiglitazone is not recommended in patients with symptomatic heart failure. Initiation of rosiglitazone in patients with established New York Heart Association (NYHA) class III or IV heart failure is contraindicated.

Myocardial infarction:
A meta-analysis of 52 clinical trials (mean duration, 6 months; 16,995 total patients), most of which compared rosiglitazone with placebo, showed rosiglitazone to be associated with a statistically significant increased risk of myocardial infarction (MI). Three other trials (mean duration, 46 months; 14,067 total patients) comparing rosiglitazone with some other approved oral antidiabetic agents or placebo showed a statistically nonsignificant increased risk of MI and a statistically nonsignificant decreased risk of death. There have been no clinical trials directly comparing the cardiovascular risk of rosiglitazone and pioglitazone, another thiazolidinedione, but in a separate trial, pioglitazone (when compared with placebo) did not show an increased risk of MI or death.”

How does this medication work?

Rosiglitazone, Avandia is a thiazolidinedione antidiabetic agent that lowers blood glucose by improving insulin sensitivity without increasing pancreatic insulin secretion, however its mechanism is dependent on the presence of insulin for activity.  It is an agonist for peroxisome proliferator-activated receptor-gamma (PPARgamma). Activation of PPARgamma receptors in the cell nucleus influences the production of a proteins involved in glucose and lipid metabolism. PPARgamma is abundant in the cells within the renal collecting tubules and fluid retention results from stimulation by thiazolidinediones which increases sodium reabsorption.

How should I take this medication?

Oral: 4-8 mg/day as a single dose or in 2 divided doses

How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same times each day with or without food unless otherwise directed, store at room temperature.

You Need to Avoid:  Significant drug interactions exist, requiring dose/frequency adjustment or avoidance so avoid starting any new medications without consulting prescriber.

What should I watch for while using this medication?

Before starting Rosiglitazone, Avandia make sure your physician is aware of any allergies or medications you currently take, if you have heart failure, ischemic heart disease, liver disease, if you have had bariatric surgery, have diabetes mellitus type 1, are pregnant, or breastfeeding. Rosiglitazone, Avandia use has been associated with rare but serious adverse events such as edema, increased risk of fractures, cardiac effects, hematologic effects, hypoglycemia, macular edema, and weight gain.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose.  Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Increased HDL cholesterol, increased LDL cholesterol, increased serum cholesterol (total), weight gain, edema, hypertension, headache, one fracture, arthralgia, back pain, upper respiratory tract infection, nasopharyngitis, trauma 

Note this is not a complete list of side effects, only the most common.