RYDAPT (Midostaurin)

RYDAPT (Midostaurin)

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What is this medication?

Midostaurin, Rydapt
Antineoplastic Agent, FLT3 Inhibitor, Tyrosine Kinase Inhibitor

Midostaurin, Rydapt is indicated for acute myeloid leukemia, mast cell leukemia, systemic mastocytosis.

How does this medication work?

Midostaurin, Rydapt is a tyrosine kinase inhibitor that inhibits multiple receptor kinases, including FLT3, FLT3 mutant kinases ITD and TKD, KIT (wild type and D816V mutant), PDGFRα/β, and members of the serine/threonine protein kinase C (PKC) family. Midostaurin, Rydapt works by blocking the several kinases on cancer cells, which prevents the cells from growing.

How should I take this medication?

Acute myeloid leukemia:
Induction (Oral): 50 mg twice daily on days 8 to 21 of each induction cycle (in combination with Daunorubicin and Cytarabine). Administer a second induction cycle if there is evidence of residual leukemia
Consolidation (Oral): 50 mg twice daily on days 8 to 21 of each 28 day consolidation cycle (in combination with high-dose cytarabine) for 4 consolidation cycles

Mast cell leukemia:
Usual (Oral): 100 mg twice daily

How to TakeTake with food at approximately 12 hour intervals. Do not open, crush or break capsules.

What should I watch for while using this medication?

Before starting Midostaurin, Rydapt make sure your physician is aware of any allergies or medications you currently take, if you are pregnant, or breastfeeding. Midostaurin, Rydapt use has been associated with rare but serious adverse events such as bone marrow suppression, GI toxicity, hypersensitivity, QT prolongation, and pulmonary toxicity.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose.  Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Edema, prolonged QT interval on ECG, headache, fatigue, dizziness, insomnia, hyperhidrosis, skin rash, hyperglycemia, hypocalcemia, hyperuricemia, increased gamma-glutamyl transferase, hyponatremia, hypoalbuminemia, hypokalemia, hyperkalemia, hypophosphatemia, hypernatremia, hypomagnesemia, nausea, vomiting, mucositis, diarrhea, increased serum lipase, abdominal pain, constipation, increased serum amylase, hemorrhoids, gastrointestinal hemorrhage, urinary tract infection, lymphocytopenia, leukopenia, anemia, thrombocytopenia, neutropenia, petechiae, prolonged partial thromboplastin time, increased serum ALT, increased serum AST, increased serum alkaline phosphatase, hyperbilirubinemia, localized infection, musculoskeletal pain, arthralgia, increased serum creatinine, renal insufficiency, upper respiratory tract infection, epistaxis, dyspnea, cough, pleural effusion, fever

Note this is not a complete list of side effects, only the most common.