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What is this medication?

Edoxaban, Savaysa/Lixiana

Brand Name US: Savaysa
Canadian Equivalent: Lixiana

Edoxaban, Savaysa/Lixiana is indicated for treatment of nonvalvular atrial fibrillation, venous thromboembolism (deep vein thrombosis and pulmonary embolism)

How does this medication work? 

Edoxaban, Savaysa/Lixiana is a selective factor Xa inhibitor, inhibits free factor Xa and prothrombinase activity and inhibits thrombin-induced platelet aggregation. Inhibition of factor Xa in the coagulation cascade reduces thrombin generation and therefore a reduction in thrombus formation and progression.  The reduction in thrombin will result in an indirect inhibition of platelet aggregation.

How should I take this medication?

Oral: 60mg once daily.

How to Take: Take with or without food.  Tablets can be crushed and mixed with applesauce or 60 to 90 mL water.  For patients with a gastric tube, mix crushed tablets with 60 to 90 mL water and administer immediately.

What should I watch for while using this medication? 

Before starting Edoxaban, Savaysa/Lixiana make sure your physician is aware of any allergies and medications you currently take.  There is an increased risk of bleeding and if Edoxaban, Savaysa/Lixiana is abruptly discontinued, there is also an inherent risk of thromboembolic complications.  

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose.  Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Hemorrhage, skin rash, vaginal bleeding, hematuria, anemia, oral hemorrhage, elevated liver enzymes, epistaxis.

Note this is not a complete list of side effects for Edoxaban, Savaysa/Lixiana only common ones.