STIVARGA (Regorafenib)

STIVARGA (Regorafenib)

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What is this medication?

STIVARGA (Regorafenib)
Antineoplastic Agent, Tyrosine Kinase InhibitorAntineoplastic Agent, Vascular Endothelial Growth Factor (VEGF) Inhibitor

STIVARGA (Regorafenib) is indicated for treatment of colorectal cancer, metastatic; GI stromal tumors; hepatocellular carcinoma.

How does this medication work?

STIVARGA (Regorafenib) is a multikinase inhibitor that targets kinases involved with tumor angiogenesis, oncogenesis, and maintenance of the tumor microenvironment which results in inhibition of tumor growth.

How should I take this medication?

Oral: Take 160 mg once daily for the first 21 days of each 28-day cycle; continue until disease progression or unacceptable toxicity

How to Take: Administer at the same time each day. Swallow tablets whole with water after a low-fat meal (containing <600 calories and <30% fat).

You Need to Avoid: Avoid grapefruit or grapefruit juice. 

What should I watch for while using this medication?

Before starting STIVARGA (Regorafenib) make sure your physician is aware of any allergies or medications you currently take, if you are pregnant, or breastfeeding.  Regorafenib use has been associated with rare but serious adverse events such as cardiovascular events, dermatologic toxicity, gastrointestinal perforation, hemorrhage, hepatotoxicity, hypersensitivity reactions, hypertension, increased risk of infection, reversible posterior leukoencephalopathy syndrome, and impaired wound healing. 

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose.  Do not take double or extra doses to make up for a missed dose.

How should I store this medication?

Store at room temperature in the original container, at 59 to 86° F (15 to 30° C). Protect from moisture. Keep the desiccant in the bottle. Keep the bottle tightly closed after first opening. Once the bottle is opened the product is to be discarded after 7 weeks. 

What are the possible side effects of using this medication?

Hypertension, alopecia, palmar-plantar erythrodysesthesia, skin rash, hypocalcemia, hypokalemia, hyponatremia, hypophosphatemia, hypothyroidism, increased amylase, weight loss, decreased appetite, diarrhea, gastrointestinal pain, increased serum lipase, nausea, stomatitis, vomiting, proteinuria, anemia, hemorrhage, increased INR, lymphocytopenia, neutropenia, thrombocytopenia, hyperbilirubinemia, increased serum alanine aminotransferase, increased serum aspartate aminotransferase, infection, fatigue, headache, pain, voice disorder, asthenia, muscle spasm, fever.

Note this is not a complete list of side effects for STIVARGA (Regorafenib), only common ones.