STRIBILD (Elvitegravir/ Cobicistat/Emtricitabine/ Tenofovir Disoproxil Fumarate)

STRIBILD (Elvitegravir/ Cobicistat/Emtricitabine/ Tenofovir Disoproxil Fumarate)

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What is this medication?

STRIBILD (Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate)
Antiretroviral, Integrase Inhibitor (Anti-HIV)Reverse Transcriptase Inhibitor, Nucleoside (Anti-HIV)Reverse Transcriptase Inhibitor, Nucleotide (Anti-HIV)Cytochrome P-450 Inhibitor

STRIBILD (Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate) is indicated for treatment of HIV-1 Infection.

STRIBILD is not approved for the treatment of chronic hepatitis B virus (HBV) infection and the safety and efficacy of STRIBILD have not been established in patients coinfected with HIV-1 and HBV. Discontinuation of STRIBILD therapy in patients coinfected with HIV-1 and HBV may be associated with severe acute exacerbations of hepatitis due to the emtricitabine or tenofovir alafenamide components of STRIBILD. Hepatic function should be monitored closely with both clinical and laboratory follow-up for at least several months in patients who are coinfected with HIV-1 and HBV and discontinue STRIBILD. If appropriate, initiation of anti-hepatitis B therapy may be warranted.

How does this medication work?

A combination of an integrase strand transfer inhibitor, CYP3A enzyme inhibitor plus nucleoside and nucleotide reverse transcriptase inhibitor.  The viral cDNA strand produced by reverse transcriptase is processed and inserted into the human genome by the enzyme HIV-1 integrase.
Elvitegravir inhibits the catalytic activity of integrase, thereby preventing integration of the proviral gene into human DNA.
Cobicistat inhibits the CYP3A subfamily and enhances systemic exposure to elvitegravir.
Tenofovir alafenamide is converted to tenofovir in the body. Tenofovir is an analog of adenosine 5′-monophosphate. Emtricitabine (a cytosine analogue) and tenofovir interfere with HIV viral RNA dependent DNA polymerase activities resulting in inhibition of viral replication.

How should I take this medication?

Oral: Take one tablet once daily (elvitegravir 150 mg+cobicistat 150 mg+emtricitabine 200 mg+tenofovir disoproxil fumarate 300 mg) 

How to Take: Take daily with food.  Swallow whole, do not crush or chew the tablet.

You Need to Avoid:  Do not start any natural health products, supplements, or new medications without informing your prescriber as this medication has many interactions with other products.

What should I watch for while using this medication?

Before starting STRIBILD (Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate), make sure your physician is aware of any allergies or medications you currently take, if you chronic hepatitis B, hepatic impairment, renal impairment, are pregnant or breastfeeding. STRIBILD use has been associated with rare but potentially serious adverse events such as decreased bone mineral density, immune reconstitution syndrome, lactic acidosis, severe hepatomegaly, osteomalacia, and renal toxicity.

What if I miss a dose?

If you miss a dose within 18 hours of the time it is usually taken, try to take it as soon as possible with food, and then take the next dose at the regularly scheduled time.  However, if you miss a dose more than 18 hours past the time it is usually taken, do not take the missed dose, but resume the usual dosing schedule.

How should I store this medication?

Keep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Diarrhea, nausea, headache, fatigue, swelling, and hives.  If you experience any of the following signs and/or symptoms such as fever, redness, rash, muscle and/or joint pain, numbness or weakness of the hands and feet, chest pain or rapid heart rate, contact your physician or pharmacist immediately.

Note this is not a complete list of side effects for STRIBILD (Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate), only common ones.