Triamterene/ Hydrochlorothiazide

Triamterene/ Hydrochlorothiazide

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What is this medication?

Triamterene+Hydrochlorothiazide, Dyazide
Diuretic, potassium sparing

Triamterene+Hydrochlorothiazide is indicated for treatment of hypertension, edema

“Alert: Black Box Warning

Abnormal elevation of serum potassium levels (5.5 mEq/L or more) can occur with hydrochlorothiazide/triamterene. Hyperkalemia is more likely to occur in patients with renal impairment and diabetes (even without evidence of renal impairment), or elderly or severely ill patients.”

How does this medication work?

Hydrochlorothiazide+Triamterene, Dyazide is a diuretic that works in two distinctly different ways.  Hydrochlorothiazide blocks sodium reabsorption in the distal tubules causing increased excretion of sodium and water as well as potassium and hydrogen ions.  While triamterene blocks sodium channels in the late distal convoluted tubule and collecting duct, which inhibits sodium reabsorption in the lumen which accounts for its natriuretic, diuretic and antihypertensive effects.

How should I take this medication?

Oral: Take 1 to 2 tablets daily.

How to Take: Can be taken with or without food.

What should I watch for while using this medication?

Before starting Hydrochlorothiazide+Triamterene, Dyazide make sure your physician is aware of any allergies or medications you currently take.  There are a number of adverse effects with using Hydrochlorothiazide+Triamterene, Dyazide which include: electrolyte disturbances (i.e. hypokalemia/hyperkalemia, hypochloremic alkalosis, hyponatremia), gout in high risk populations, photosensitivity and should be used with caution in patients with diabetes, hepatic and/or renal impairment, hypercholesterolemia, kidney stones, parathyroid disease and systemic lupus erythematosus (SLE).

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose.  Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

The frequency of side effects has not been recorded but have included:

Angina, cardiac arrhythmia, tachycardia, orthostatic hypotension, anxiety, depression, dizziness, headache, vertigo, skin rash, photosensitivity, urticaria, acidosis, diabetes mellitus, glycosuria, electrolyte disturbances, abdominal pain, constipation, diarrhea, nausea, pancreatitis, tongue discoloration, vomiting, urine discoloration, jaundice, blurred vision.

Note this is not a complete list of side effects, only common ones.