TRIZIVIR (Abacavir/Lamivudine/ Zidovudine)

TRIZIVIR (Abacavir/Lamivudine/ Zidovudine)

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VIIV HEALTHCARE
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prescription

What is this medication?

TRIZIVIR (Abacavir/Lamivudine/ Zidovudine)
Antiretroviral, Reverse Transcriptase Inhibitor (Anti-HIV)

TRIZIVIR, a combination of abacavir, lamivudine, and zidovudine is indicated for the treatment of Human Immunodeficiency Virus (HIV) infection in adult patients.

ALERT: WARNING
TRIZIVIR has been associated with hematologic toxicity including neutropenia and severe anemia in advanced HIV-1 disease.  Prolonged use of TRIZIVIR has been shown to cause symptomatic myopathy.  Lactic acidosis and severe hepatomegaly with steatosis have been reported with using nucleoside analogues.  Severe exacerbations of hepatitis B have been reported in patients who are coinfected with hepatitis B virus (HBV) and HIV-1.

All patients should be screened for the HLA-B*5701 allele prior to initiating or reinitiating treatment with TRIZIVIR.  Patients who carry the HLA-B*5701 allele are at high risk for experiencing a hypersensitivity reaction to abacavir, a component of TRIZIVIR although, hypersensitivity reactions have occurred in patients who do not carry the HLA-B*5701 allele. Serious and sometimes fatal hypersensitivity reactions have been associated with therapy with abacavir sulfate and other abacavir-containing products.

How does this medication work?

TRIZIVIR is a combination of abacavir, lamivudine, and zidovudine which act synergistically through different mechanisms of action to inhibit reverse transcriptase to reduce viral replication and to delay the emergence of mutations conferring resistance.  Abacavir is a guanosine analogue which is phosphorylated to carbovir triphosphate which interferes with HIV viral RNA-dependent DNA polymerase resulting in inhibition of viral replication.  Lamivudine is a cytosine analog. In vitro, lamivudine is triphosphorylated, the principal mode of action is inhibition of HIV reverse transcription via viral DNA chain termination; inhibits RNA- and DNA-dependent DNA polymerase activities of reverse transcriptase. In hepatitis B, the monophosphate form of lamivudine is incorporated into the viral DNA by hepatitis B virus polymerase, resulting in DNA chain termination.  Zidovudine is a thymidine analog which interferes with the HIV viral RNA-dependent DNA polymerase resulting in inhibition of viral replication; nucleoside reverse transcriptase inhibitor.

How should I take this medication?

Oral: Take one tablet (abacavir 300mg/lamivudine 150mg/zidovudine 300mg) twice daily.

How to Take: Take without regard to meals.

Note: Triple NRTI regimens are not recommended in HIV treatment guidelines due to suboptimal virologic activity.

TRIZIVIR is contraindicated in patients with a prior hypersensitivity reaction to abacavir and in HLA-B*5701-positive patients.
You should be screened for the HLA-B*5701 allele prior to initiating therapy with TRIZIVIR.

Discontinue TRIZIVIR immediately if a hypersensitivity reaction is suspected, regardless of HLA-B*5701 status. 
Following a hypersensitivity reaction to TRIZIVIR, never restart TRIZIVIR or any other abacavir-containing product because more severe symptoms, including death can occur within hours.

What should I watch for while using this medication?

Before starting TRIZIVIR (Abacavir/Lamivudine/ Zidovudine) make sure your physician is aware of any allergies or medications you currently take, and activities you perform.
Abacavir/Lamivudine/Zidovudine has been associated with series adverse reactions including hematologic toxicity, including neutropenia and severe anemia.  Hypersensitivity reactions have occurred in patients taking the combination Abacavir/Lamivudine/Zidovudine.  Patient’s who carry the HLA-B*5701 allele have been found to be at higher risk for a hypersensitivity reaction. Abacavir/Lamivudine/Zidovudine can trigger the development of an immune reconstitution syndrome which can result in an inflammatory response to an indolent or residual infection. Abacavir/Lamivudine/Zidovudine can also cause lactic acidosis, severe hepatomegaly, lipoatrophy, myopathy and pancreatitis. The combination Abacavir/Lamivudine/Zidovudine should be used with caution in patients with coronary heart disease, hepatic and/or renal impairment.

What if I miss a dose?

If you forget to take a dose of your medication, take it as soon as you remember. Then continue as before. Do not take a double dose to make up for forgotten individual doses. If therapy is stopped with TRIZIVIR (Abacavir/Lamivudine/ Zidovudine) because of side effects or illness, then check with your doctor before restarting therapy to make sure that symptoms of a hypersensitivity reaction have not been missed.

How should I store this medication?

Keep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Headache, fatigue, malaise, depression, anxiety, skin rash, nausea, diarrhea, pancreatitis, neutropenia, increased serum ALT, hypersensitivity, viral infection, fever and chills, increased creatine phosphokinase.

Note this is not a complete list of side effects for TRIZIVIR (Abacavir/Lamivudine/ Zidovudine), only common ones.