VELPHORO (Sucroferric Oxyhydroxide)

VELPHORO (Sucroferric Oxyhydroxide)

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What is this medication?

Sucroferric Oxyhydroxide, Velphoro
Phosphate binder

Velphoro is officially indicated for hyperphosphatemia

How does this medication work? 

Velphoro is a mixture of polynuclear iron(III)-oxyhydroxide (pn- FeOOH), sucrose, and starches and phosphate in the aqueous environment of the GI tract via ligand exchange between hydroxyl groups and/or water in sucroferric oxyhydroxide and dietary phosphate. Reduced dietary phosphate absorption results in reduced serum phosphorus levels and calcium-phosphorus product levels.

How should I take this medication? 

Usual (Oral): one tablet (500mg iron) 3 times daily with meals.  May titrate dosage weekly, starting after 1 week in increments of 500mg iron per day as needed to maintain appropriate serum phosphorus levels (≤5.5 mg/dL); usual maintenance dose: 3 to 4 tablets (1.5 to 2 g iron/day); doses of up to 6 tablets (3 g iron/day) have been evaluated.

Note: one tablet contains 2.5 g of sucroferric oxyhydroxide which is equivalent to 500 mg of iron.

How to Take: Tablets must be chewed or crushed; do not swallow whole. Must administer with meals. The total daily dose should be divided among meals.

What should I watch for while using this medication?

Before starting Velphoro make sure your physician is aware of any allergies or medications you currently take, pre-existing medical conditions and activities you perform.  There are no contraindications in using Velphoro.  However, patients with gastrointestinal disorders, history of hemochromatosis, hepatic disease, and peritonitis during peritoneal dialysis should be monitored closely for iron homeostasis.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication? 

Diarrhea, darkening of stools, nausea, skin rash, dental discoloration

Note this is not a complete list of side effects, only the most common.