VIMOVO (Naproxen/Esomeprazole)
VIMOVO (Naproxen/Esomeprazole)
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VIMOVO (Naproxen/Esomeprazole)

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What is this medication?

Naproxen+Esomeprazole, Vimovo
Nonsteroidal Anti-Inflammatory Drug (NSAID), Proton Pump Inhibitor

Vimovo is indicated for osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, juvenile idiopathic arthritis

“Alert: US Warning

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) around 20 weeks’ gestation or later in pregnancy may cause fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment, which may be fatal. These effects are usually observed after days to weeks of NSAID use but may occur as soon as 48 hours after NSAID initiation. If NSAID use is necessary between 20 and 30 weeks of pregnancy, use should be limited to the lowest effective dose and shortest duration possible.

NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including MI and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use.  Naproxen/esomeprazole is contraindicated in the setting of CABG surgery.

NSAIDs cause an increased risk of serious GI adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events.”

How does this medication work? 

Vimovo contains a combination of esomeprazole and naproxen. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that reversibly inhibits cyclooxygenase-1 and 2 (COX-1 and 2) enzymes, which result in decreased formation of prostaglandin precursors; has antipyretic, analgesic, and anti-inflammatory properties.  Esomeprazole is a proton pump inhibitor which decreases acid secretion in gastric parietal cells.

How should I take this medication? 

Usual (Oral):  one tablet twice daily.

Note: If a total daily dose of esomeprazole <40 mg is necessary, alternate treatment should be considered.

How to Use:  Administer dose at least 30 minutes prior to meals. Swallow tablets whole; do not chew, crush, dissolve, or split.  Do not substitute naproxen/esomeprazole with single-ingredient products of naproxen and esomeprazole magnesium.

What should I watch for while using this medication?

Before starting Naproxen+Esomeprazole, Vimovo make sure your physician is aware of any allergies or medications you currently take, and activities you perform. Naproxen+Esomeprazole, Vimovo has been reported to increase the risk of cardiovascular thrombotic events, including MI and stroke and subsequently should be used with caution in patients with hypertension and/or edema.  Do not use Naproxen+Esomeprazole, Vimovo in patients who have heart failure and/or a recent MI.  Naproxen+Esomeprazole, Vimovo can increase the risk and cause clotridioides difficile-associated diarrhea, dizziness, drowsiness, blurred vision, autoimmune diseases (i.e. cutaneous lupus erythematosus, systemic lupus erythematosus), fractures, fundic gland polyps, gastric inflammation, ulceration and perforation, hepatic effects, hyperkalemia, hypomagnesemia, renal impairment, tubulointerstitial nephritis, and fatal serious skin reactions including exfoliative dermatitis.  Naproxen+Esomeprazole, Vimovo should not be used in patients with aspirin-sensitive asthma, undergoing coronary artery bypass graft (CABG), hepatic impairment and advanced renal disease.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication? 

Gastritis, peripheral edema, constipation, diarrhea, dysgeusia, flatulence, upper abdominal pain, dizziness, headache, upper respiratory tract infection, urinary tract infection

Note this is not a complete list of side effects, only the most common.