XYLAC (Loxapine)
XYLAC (Loxapine)
XYLAC (Loxapine)
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XYLAC (Loxapine)

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What is this medication?

Loxapine, Xylac
First Generation (typical) Antipsychotic

Loxapine/Xylac is officially indicated for schizophrenia and agitation associated with schizophrenia or bipolar I disorder.  (may be used for other conditions not listed)

How does this medication work?

Loxapine, Xylac is a dibenzoxazepine antipsychotic that blocks the D1 and D2 dopamine receptors postsynaptically in the mesolimbic pathway in the brain with some serotonin 5-HT2 antagonism as well.  The brains response to altered chemistry results in desired effects.

How should I take this medication?

10-250mg divided into 2-4 daily dosages depending on what condition it is used for and patient response. 

How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same times each day unless otherwise directed, store at room temperature.

You Need to Avoid: Operating heavy machinery or driving at least until you know how the medication affects you.  Do not stop this medication suddenly, make sure your physician is aware and can create a tapering schedule so you can come off slowly and prevent any withdrawal symptoms.   This medication has many drug interactions so ask your pharmacist before starting any over the counter medications or supplements.

What should I watch for while using this medication?

Before starting Loxapine, Xylac make sure your physician is aware of any allergies or medications you currently take, if you have kidney disease, liver disease, a history of seizures, cardiovascular disease, dementia or are pregnant or breastfeeding. 

This medication also required regular bloodwork and follow up with your physician to monitor for adverse reactions

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose.  Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

Orthostatic hypotension, tachycardia, syncope, weight gain, constipation, hunger, dry mouth, alopecia, polydipsia (extreme thirst), urinary retention, impotence, blurred vision, increased serum prolactin, increased liver enzymes, weakness, agitation, dizziness, drowsiness, fatigue, temperature dysregulation, slurred speech, headache, insomnia, withdrawal syndrome, and extrapyramidal reaction (involuntary movement)

Note- this is not a complete list of side effects, of which are generally dosage dependent.  When higher doses are required the physician has weighed the risks and found the benefits to be greater, however regular monitoring (blood sugar, cholesterol, blood pressure, etc.) is important to make sure this does not change. May rarely cause neuroleptic malignant syndrome.